ArticleDevelopmental medicine and child neurology2025
Alterations in cortical and subcortical neuroanatomy and associations with behavior in females with fragile X syndrome.
Article in Developmental medicine and child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- MRI-based cortical morphometry in traumatic brain injury: a pilot longitudinal study.Neuroradiology · 2026Article
- Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability.Autism research : official journal of the International Society for Autism Research · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
aimTo address substantial gaps in the literature on neuroanatomical variations in females with fragile X syndrome (FXS).
methodSurface-based modeling techniques were applied to the magnetic resonance imaging of 45 females with FXS (mean age = 10 years 9 months, range 6 years-16 years 4 months, SD = 2 years 9 months) and 33 age-matched and developmentally matched females without FXS to elucidate differences in cortical gray matter volume, surface area, and thickness. Gray matter volumes in subcortical regions were examined to ascertain differences in subcortical volume.
resultsIn females with FXS, cortical volume was greater bilaterally in the occipital pole and smaller in the right postcentral gyrus. Seven regions demonstrated lower surface area in participants with FXS, while cortical thickness was significantly greater over the posterior and medial surfaces in the group with FXS. Subcortical region of interest analyses demonstrated greater volume in the caudate nucleus, globus pallidus, and nucleus accumbens in the group with FXS. Global gray matter volume, pial thickness, and surface area were associated with behavioral outcomes in the group with FXS but not in the comparison group.
interpretationFemales with FXS demonstrated unique cortical and subcortical gray matter anatomy relative to a matched comparison group. These findings may be relevant to the pathogenesis of the FXS behavioral phenotype and provide insights into behavioral interventions targeted to this population.
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