Evidence map›Paper›PMID 39279209›Full record

ArticleJournal of Crohn's & colitis2025

Oxidized Polyunsaturated Fatty Acid Promotes Colitis and Colitis-Associated Tumorigenesis in Mice.

Weicang Wang, Yuxin Wang, Katherine Z Sanidad, Yige Wang, Jianan Zhang, Wenqi Yang, Quancai Sun, Ipek Bayram, Renhua Song, Haixia Yang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Weicang WangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.ORCID 0000-0002-2722-507X
Yuxin WangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Katherine Z SanidadDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Yige WangDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Jianan ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Wenqi YangDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Quancai SunDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Ipek BayramDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Renhua SongEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia.
Haixia YangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
David JohnsonDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Heather L ShermanDepartment of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Daeyoung KimDepartment of Mathematics & Statistics, University of Massachusetts, Amherst, MA, USA.
Lisa M MinterMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.
Justin J-L WongEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia.
Melody Y ZengGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Eric A DeckerDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.
Guodong ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA, USA.

Funding

USDA/Hatch MAS00492USDA NIFA 2016-67017-24423
6 · The paper itself

Abstract

BACKGROUND AND

aimsHuman studies suggest that a high intake of polyunsaturated fatty acid (PUFA) is associated with an increased risk of inflammatory bowel disease (IBD). PUFA is highly prone to oxidation. To date, it is unclear whether unoxidized or oxidized PUFA is involved in the development of IBD. Here, we aim to compare the effects of unoxidized PUFA vs oxidized PUFA on the development of IBD and associated colorectal cancer.

methodsWe evaluated the effects of unoxidized and oxidized PUFA on dextran sodium sulfate (DSS)-induced and IL-10 knockout-induced colitis, and azoxymethane/DSS-induced colon tumorigenesis in mice. Additionally, we studied the roles of gut microbiota and Toll-like receptor 4 (TLR4) signaling involved.

resultsAdministration of a diet containing oxidized PUFA, at human consumption-relevant levels, increases the severity of colitis and exacerbates the development of colitis-associated colon tumorigenesis in mice. Conversely, a diet rich in unoxidized PUFA does not promote colitis. Furthermore, oxidized PUFA worsens colitis-associated intestinal barrier dysfunction and leads to increased bacterial translocation, and it fails to promote colitis in TLR4 knockout mice. Finally, oxidized PUFA alters the diversity and composition of gut microbiota, and it fails to promote colitis in mice lacking the microbiota.

conclusionsThese results support that oxidized PUFA promotes the development of colitis and associated tumorigenesis in mouse models via TLR4- and gut microbiota-dependent mechanisms. Our findings highlight the potential need to update regulation policies and industrial standards for oxidized PUFA levels in food.

Indexed as

CarcinogenesisColitisColitis-Associated NeoplasmsColonic NeoplasmsFatty Acids, UnsaturatedAnimalsAzoxymethaneBacterial TranslocationDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeInterleukin-10MiceMice, Inbred C57BLMice, KnockoutOxidation-ReductionAzoxymethaneDextran SulfateFatty Acids, UnsaturatedInterleukin-10Tlr4 protein, mouseToll-Like Receptor 4colitiscolitis-associated tumorigenesislipid oxidationPolyunsaturated fatty acid

Identifiers

PMID39279209
PMCPMC13032040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.