Evidence map›Paper›PMID 39279120›Full record

ArticleCurrent medicinal chemistry2026

Targeting Fructosamine Oxidase (Amadoriase II) in

Imane Yamari, Oussama Abchir, Meriem Khedraoui, Abdelkbir Errougui, Mohammed Talbi, Abdelouahid Samadi, MHammed El Kouali, Samir Chtita

Abstract read
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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Imane YamariLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Oussama AbchirLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Meriem KhedraouiLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Abdelkbir ErrouguiLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Mohammed TalbiLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Abdelouahid SamadiDepartment of Chemistry, College of Science, United Arab Emirates University UAEU, P.O. Box No. 15551, Al Ain, UAE.
MHammed El KoualiLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.
Samir ChtitaLaboratory of Analytical and Molecular Chemistry, Department of Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, 7955, Morocco.ORCID 0000-0003-2344-5101

Funding

United Arab Emirates University and Zayed Center for Health Sciences G00003680
6 · The paper itself

Abstract

introductionAspergillus fumigatus, a significant fungal pathogen, poses a threat to human health, especially in immunocompromised individuals. Addressing the need for novel antifungal strategies, this study employs virtual screening to identify potential inhibitors of Fructosamine oxidase, also known as Amadoriase II, a crucial enzyme in Aspergillus fumigatus (PDB ID: 3DJE).

methodsVirtual screening of 81,197 triazole derivatives was subjected to computational analysis, aiming to pinpoint molecules with high binding affinity to the active site of Fructosamine oxidase. Subsequently, an in-depth ADMET analysis assessed the pharmacokinetic properties of lead compounds, ensuring their viability for further development. Molecular dynamics simulations were performed to evaluate the stability of top-ranked compounds over time.

resultsThe results unveil a subset of triazole derivatives displaying promising interactions, suggesting their potential as inhibitors for further investigation.

conclusionThis approach contributes to the development of targeted antifungal agents, offering a rational starting point for experimental validation and drug development against Aspergillus fumigatus infections.

Indexed as

Antifungal AgentsAspergillus fumigatusEnzyme InhibitorsMolecular Dynamics SimulationTriazolesDrug Evaluation, PreclinicalHumansMolecular StructureStructure-Activity RelationshipAntifungal AgentsEnzyme InhibitorsTriazolesADMETAspergillus fumigatusfructosamine oxidasekeratin- rich tissue.molecular dockingmolecular dynamics

Identifiers

PMID39279120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.