Evidence map›Paper›PMID 39278928›Full record

Trial reportBMC ophthalmology2024

Effect of virtual reality-based visual training for myopia control in children: a randomized controlled trial.

Zihang Xu, Aiqi Zou, Li Li, Yan Wu, Wenting Cai, Jingyang Ma, Jing Yu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06250920 (Effect of Virtual Reality-Based Visual Training for Myopia Control in Children), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06250920 nacompletednot on this map

Effect of Virtual Reality-Based Visual Training for Myopia Control in Children: a Randomized Controlled Trial

TypeinterventionalSponsorShanghai 10th People's HospitalRan2020 to 2021Enrolled65ConditionsMyopia, Myopia, ProgressiveArmsVirtual reality visual training
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zihang Xu *Department of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Aiqi Zou *Department of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Li LiDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Yan WuDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Wenting CaiDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Jingyang MaDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China.
Jing YuDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200072, China. dryujing@aliyun.com.

Funding

Project for Health Research of Anhui Province AHWJ2023A20568
6 · The paper itself

Abstract

backgroundTo assess the efficacy and safety of virtual reality-based visual training (VRVT) in myopia control among children.

methodsThe randomized, parallel-group, single-blind clinical trial conducted at the Department of Ophthalmology of Shanghai Tenth People's Hospital enrolled 65 low-myopic children (aged 8 to 13 years) with cycloplegic spherical equivalent (SE) between - 0.50 and - 3.00 diopters (D), astigmatism less than - 1.00 D, anisometropia less than 1.50D, and best corrected visual acuity (BCVA) more than 0.0 logarithm (LogMAR) of the minimum angle of resolution. The participants were enrolled in December 2020, and the follow-up of this study concluded on August 2021. Children were assigned randomly to the intervention group (VRVT plus single-vision spectacle [SVS]) and the control group (only SVS without receiving VRVT). The intervention group was administered for 20 min per day with VRVT under parental supervision at home. The primary outcome was changes in axial length (AL) at 3 months. Macular choroidal thickness (mCT) was regarded as a key secondary outcome.

resultsAmong 65 participants (mean age: 10.8 years, 52.3% male), 60 children (92.3%) who completed the 3-month intervention and 6-month follow-up were included in the analysis (30 in the intervention group and 30 in the control group). The changes of AL were 0.063 ± 0.060 mm (95% confidence interval [CI], 0.074 to 0.119 mm) in the intervention group and 0.129 ± 0.060 mm (95% CI, 0.107 to 0.152 mm) and in the control group at 3 months (t = - 2.135, P = 0.037), and the mean difference between the two groups was 0.066 mm. The change of mCT were 22.633 ± 36.171 μm (95% CI, 9.127 to 36.140 μm) in the intervention group and - 3.000 ± 31.056 μm (95% CI, - 14.597 to 8.597 μm) in the control group at 3 months (t = 2.945, P = 0.005). VR vertigo was the most common adverse event which was occurred in two children (2/30, 6.67%) in the intervention group.

conclusionsVRVT is a promising method for myopia control in children with good user acceptability. Among children aged 8 to 13 years with low-myopia, nightly use of VRVT resulted in slowing myopia progression.

trial registrationThis protocol was registered with ClinicalTrials.gov (NCT06250920), retrospectively registered on 01 February 2024.

Indexed as

MyopiaRefraction, OcularVirtual RealityVisual AcuityAdolescentAxial Length, EyeChildEyeglassesFemaleFollow-Up StudiesHumansMaleSingle-Blind MethodTreatment OutcomeChildrenMyopia controlRandomized controlled trialVirtual realityVisual training

Identifiers

PMID39278928
PMCPMC11404007

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.