ArticleBMC plant biology2024
Flagellin Induced GABA-shunt improves Drought stress tolerance in Brassica napus L.
Article in BMC plant biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effects of Exogenous Monosodium Glutamate on GABA Accumulation and Volatile/Nonvolatile Metabolites in Black Highland Barley.Food science & nutrition · 2026Article
- Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress.Planta · 2026Review
- Overexpression of IbGAD4 enhances salt tolerance in sweetpotato by modulating the GABA pathway.BMC plant biology · 2026Article
- Biostimulants and their role in increasing cereal crops' resistance to drought stress.Frontiers in plant science · 2026Review
- Widely targeted metabolic profiling reveals drought resistance mechanisms in alfalfa leaves.BMC plant biology · 2025Article
- Article
- γ-Aminobutyric Acid (GABA) Metabolic Bypass Plays a Crucial Role in Stress Tolerance and Biofilm Formation inFoods (Basel, Switzerland) · 2025Article
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Abstract
backgroundHigh GABA levels and its conversion to succinate via the GABA shunt are known to be associated with abiotic and biotic stress tolerance in plants. The exact mode of action is still under debate and it is not yet clear whether GABA is a common component of the plant stress defense process or not. We hypothesized that if it is a common route for stress tolerance, activation of GABA-shunt by a biotic stressor might also function in increased abiotic stress tolerance. To test this, Brassica napus plants treated with Flagellin-22 (Flg-22) were exposed to drought stress and the differences in GABA levels along with GABA-shunt components (biosynthetic and catabolic enzyme activities) in the leaf and root samples were compared. In order to provide a better outlook, MYC2, MPK6 and ZAT12, expression profiles were also analyzed since these genes were recently proposed to function in abiotic and biotic stress tolerance.
resultsBriefly, we found that Flg treatment increased drought stress tolerance in B. napus via GABA-shunt and the MAPK cascade was involved while the onset was different between leaves and roots. Flg treatment promoted GABA biosynthesis with increased GABA content and GAD activity in the leaves. Better performance of the Flg treated plants under drought stress might be dependent on the activation of GABA-shunt which provides succinate to TCA since GABA-T and SSADH activities were highly induced in the leaves and roots. In the transcript analysis, Flg + drought stressed groups had higher MYC2 transcript abundances correlated well with the GABA content and GABA-shunt while, MPK6 expression was induced only in the roots of the Flg + drought stressed groups. ZAT12 was also induced both in leaves and roots as a result of Flg-22 treatment. However, correlation with GABA and GABA-shunt could be proposed only in Flg + drought stressed group.
conclusionWe provided solid data on how GABA-shunt and Fgl-22 are interacting against abiotic stress in leaf and root tissues. Fgl-22 induced ETI activated GABA-shunt with a plausible cross talk between MYC2 and ZAT12 transcription factors for drought stress tolerance in B. napus.
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