Evidence map›Paper›PMID 39278836›Full record

ArticleChemistry & biodiversity2025

Hybrid Molecules Containing Methotrexate, Vitamin D, and Platinum Derivatives: Synthesis, Characterization, In Vitro Cytotoxicity, In Silico ADME Docking, Molecular Docking and Dynamics.

Zintle Mbese, Mpho Choene, Eric Morifi, M Nwamadi, Samson Adeyemi, Abel Kolawole Oyebamiji, Adedapo S Adeyinka, Blassan George, Blessing Atim Aderibigbe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zintle MbeseDepartment of Chemistry, University of Fort Hare, Alice Campus, 5700, Alice, Eastern Cape, South Africa.
Mpho ChoeneDepartment of Biochemistry, University of Johannesburg, Kingsway Campus, Auckland Park, 2006, Johannesburg, South Africa.
Eric MorifiSchool of Chemistry, Mass Spectrometry Division, University of Witwatersrand, 2050, Johannesburg, South Africa.
M NwamadiDepartment of Chemistry, University of Johannesburg, Auckland Park Campus, 2006, Johannesburg, South Africa.
Samson AdeyemiWits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Abel Kolawole OyebamijiDepartment of Chemistry and Industrial Chemistry, Bowen University, Iwo, Osun State, Nigeria.ORCID https://orcid.org/0000-0002-2318-8208
Adedapo S AdeyinkaResearch Centre for Synthesis and Catalysis, Department of Chemical Sciences, University of Johannesburg, Auckland Park, 2006, Johannesburg, South Africa.
Blassan GeorgeLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein Campus, 2028, Johannesburg, South Africa.
Blessing Atim AderibigbeDepartment of Chemistry, University of Fort Hare, Alice Campus, 5700, Alice, Eastern Cape, South Africa.ORCID https://orcid.org/0000-0003-1157-7481

Funding

Govan Mbeki Research and Development CenterNational Research FoundationSouth African Medical Research CouncilUniversity of Fort Hare
6 · The paper itself

Abstract

Designing hybrid-based drugs is one promising strategy for developing effective anticancer drugs that explore combination therapy to enhance treatment efficacy, overcome the development of drug resistance, and lower treatment duration. Bisphosphonates and Vitamin D are commonly administered drugs for the treatment of bone diseases and the prevention of bone metastases. Platinum-based and methotrexate are widely used anticancer drugs in clinics. However, their use is hampered by adverse side effects. Hybrid-based compounds containing either bisphosphonate, vitamin D, platinum-based, or methotrexate were synthesized and characterized using FTIR,

Indexed as

3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)Antineoplastic AgentsDrug Screening Assays, AntitumorMethotrexateMolecular Docking SimulationVitamin DCell ProliferationCell SurvivalDose-Response Relationship, DrugHumansMCF-7 CellsMolecular Dynamics SimulationMolecular StructurePlatinumStructure-Activity Relationship3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)AKR1C2 protein, humanAntineoplastic AgentsMethotrexatePlatinumVitamin DCytotoxicityIn Silico ADMEMethotrexateMolecular dockingVitamin D

Identifiers

PMID39278836
PMCPMC11741164

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.