Evidence map›Paper›PMID 39278811›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2025

Role of B cells in intratumoral MBTA immunotherapy of murine pheochromocytoma model.

Ondrej Uher, Katerina Hadrava Vanova, Katerina Petrlakova, Rachael Labitt, Radka Lencova, Andrea Frejlachova, Juan Ye, Herui Wang, Michal Masarik, Jan Zenka and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026
    Review
  2. Approach to the Patient With Metastatic Pheochromocytoma and Paraganglioma.The Journal of clinical endocrinology and metabolism · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ondrej UherSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: ondrej.uher@nih.gov.
Katerina Hadrava VanovaSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: katerina.hadravavanova@nih.gov.
Katerina PetrlakovaSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno 62500 Czech Republic. Electronic address: katerina.petrlakova@med.muni.cz.
Rachael LabittResearch Animal Management Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: rachael.labitt@nih.gov.
Radka LencovaDepartment of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: lencor00@prf.jcu.cz.
Andrea FrejlachovaDepartment of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: frejla00@prf.jcu.cz.
Juan YeNeuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: juan.ye@nih.gov.
Herui WangNeuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: herui.wang@nih.gov.
Michal MasarikDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno 62500 Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno 62500, Czech Republic; BIOCEV (Biotechnology and Biomedicine Center in Vestec), First Faculty of Medicine, Charles University, Vestec 25250, Czech Republic. Electronic address: masarik@med.muni.cz.
Jan ZenkaDepartment of Medical Biology, Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic. Electronic address: jzenka@prf.jcu.cz.
Zhengping ZhuangNeuro-Oncology Branch, National Cancer Institute, NIH, Bethesda 20892, MD, USA. Electronic address: zhengping.zhuang@nih.gov.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda 20892, MD, USA. Electronic address: karel@mail.nih.gov.

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Diagnosis &Pathophysiology of PheochromocytomaZ01HD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2001 to 2008
$1.7M
Intramural NIH HHS Z01 HD008735Intramural NIH HHS ZIA HD008735
6 · The paper itself

Abstract

Immunotherapy represents a revolutionary advancement in cancer treatment, which has traditionally focused on T cells; however, the role of B cells in cancer immunotherapy has gained interest because of their role in antigen presentation, antibody production, and cytokine release. In this study, we examined the role of B cells in previously developed intratumoral MBTA therapy (mannan-BAM, TLR ligands, and anti-CD40 antibody) in murine models of MTT pheochromocytoma. The results indicated that B cells significantly enhance the success of MBTA therapy, with wild-type mice exhibiting a lower tumor incidence and smaller tumors compared with B cell-deficient mice. Increased IL-6 and TNF-alpha levels indicated severe inflammation and a potential cytokine storm in B cell-deficient mice. Neutralization of TNF-alpha ameliorated these complications but resulted in increased tumor recurrence. The results highlight the important role of B cells in enhancing the immune response and maintaining immune homeostasis during MBTA therapy. Our findings offer new insights into improving therapeutic outcomes.

Indexed as

Adrenal Gland NeoplasmsB-LymphocytesImmunotherapyPheochromocytomaAnimalsDisease Models, AnimalInterleukin-6MiceMice, Inbred C57BLTumor Necrosis Factor-alphaInterleukin-6Tumor Necrosis Factor-alphaB cellscytokine stormintratumoral immunotherapymelanomapheochromocytoma

Identifiers

PMID39278811
PMCPMC11788020

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.