Evidence map›Paper›PMID 39278806›Full record

ArticleSleep health2024

Association of inadequate sleep with mortality among persons who inject drugs.

Jing Sun, Hsing-Yu Hsu, Jill A Rabinowitz, David W Sosnowski, Damani A Piggott, Shruti H Mehta, Brion S Maher, Adam P Spira, Gregory D Kirk

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In one paragraph

Article in Sleep health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing SunDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. Electronic address: jsun54@jhmi.edu.
Hsing-Yu HsuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jill A RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
David W SosnowskiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Damani A PiggottDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Shruti H MehtaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Brion S MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Adam P SpiraDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA; Johns Hopkins Center on Aging and Health, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Gregory D KirkDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
NIDA Epidemiology Training Program: Johns Hopkins UniversityT32DA007292 · NIDA · JOHNS HOPKINS UNIVERSITY · PI RENEE M. JOHNSON, Brion S Maher · 1993 to 2026
$17.7M
Pharmacogenomics of ART adherence and effectiveness in the ALIVE CohortR01DA047064 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D, MAHER, BRION S · 2018 to 2023
$5.8M
The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)R01HL090483 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2007 to 2011
$4.4M
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
Collaboration on HIV and AgingResearch through the Study of MitochondriaK01AI162247 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Jing Sun · 2022 to 2026
$677k
NHLBI NIH HHS R01 HL090483NIAID NIH HHS K01 AI162247NIAID NIH HHS K24 AI118591NIDA NIH HHS R01 DA047064NIDA NIH HHS T32 DA007292NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

backgroundInadequate sleep is associated with all-cause mortality in the general population. Substance use has adverse effects on sleep, and insomnia symptoms are common among people with HIV. Therefore, persons who inject drugs may face a heightened risk of adverse outcomes from inadequate sleep. We evaluated the association of inadequate sleep with mortality among persons who inject drugs in a long-standing community cohort.

methodsParticipants were from the AIDS Linked to the IntraVenous Experience (ALIVE) study, a cohort of persons who inject drugs in Baltimore, Maryland, USA. From 2005-2020, perceived sleep adequacy and duration were assessed semiannually using survey. Mortality data were obtained through linkage to the National Death Index-Plus. Cause of death was independently characterized and validated by three physicians. Hazards of all-cause and cause-specific mortality were evaluated using Cox regression accounting for repeated measurements.

resultsA total of 2633 participants were included, with a median age at entry of 45.8years; 32.5% were female, and 75% were Black. After adjustment for demographics, mental health, and comorbidities, inadequate sleep was associated with a 32% greater hazard of all-cause mortality (hazard ratio: 1.32, 95% confidence interval: 1.12-1.55) and a 67% greater hazard of HIV/infectious disease-related deaths (hazard ratio: 1.67, 95% confidence interval: 1.15-2.42). Short (<6 hours) and long (≥8 hours) duration of sleep were both associated with higher hazard of all-cause and chronic disease-related mortality (all p < .05).

conclusionsSleep plays a critical role in longevity in persons who inject drugs. Research is needed to determine whether interventions targeting sleep improve health and longevity in persons who inject drugs.

Indexed as

Substance Abuse, IntravenousAdultBaltimoreCause of DeathCohort StudiesFemaleHumansMaleMiddle AgedHIVMortalityPersons who inject drugsSleep adequacySleep duration

Identifiers

PMID39278806
PMCPMC11624996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.