Evidence map›Paper›PMID 39278787›Full record

ReviewTrends in microbiology2025

The conserved AvrE family of bacterial effectors: functions and targets during pathogenesis.

Laura Herold, Sera Choi, Sheng Yang He, Cyril Zipfel

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laura HeroldInstitute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.
Sera ChoiInstitute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland.
Sheng Yang HeDepartment of Biology, Duke University, Durham, NC, USA; Howard Hughes Medical Institute, Duke University, Durham, NC, USA.
Cyril ZipfelInstitute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, Zurich, Switzerland; The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK. Electronic address: cyril.zipfel@botinst.uzh.ch.

Funding

Establishment of an aqueous environment as a novel mechanism of bacterial pathogenesisR01AI155441 · NIAID · DUKE UNIVERSITY · PI HE, SHENG YANG · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI155441
6 · The paper itself

Abstract

The AvrE family of type III secreted effectors are highly conserved among many agriculturally important phytopathogenic bacteria. Despite their critical roles in the pathogenesis of phytopathogenic bacteria, the molecular functions and virulence mechanisms of these effectors have been largely unknown. However, recent studies have identified host-interacting proteins and demonstrated that AvrE family effectors can form water-permeable channels in the plant plasma membrane (PM) to create a hydrated and nutrient-rich extracellular space (apoplast) required for disease establishment. Here, we summarize these recent discoveries and highlight open questions related to AvrE-targeted host proteins.

Indexed as

BacteriaBacterial ProteinsPlant DiseasesPlantsVirulence FactorsCell MembraneHost-Pathogen InteractionsType III Secretion SystemsVirulenceBacterial ProteinsType III Secretion SystemsVirulence Factorsabscisic acidapoplast hydrationbacteriachannelpathogenesisreceptor kinases/protein phosphatasestype III secreted effectorvirulence effector

Identifiers

PMID39278787
PMCPMC12183717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.