Evidence map›Paper›PMID 39278203›Full record

ArticleNeonatology2025

Neonatal Linear Immunoglobulin A Bullous Dermatosis: A Critical Case Recovering after Prompt Recognition, Intensive Management, and Breastfeeding Interruption - A Case Report.

Dimitra Papasavva, Leila Dosso, Marie-Anne Morren, Lionel Fontao, Laura Bruschi, François Gorostidi, Thomas Ferry, Emmanuella Guenova, Céline J Fischer Fumeaux, Sébastien Joye

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Article in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Dimitra PapasavvaDepartment Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, dpapasavva1@gmail.com.
Leila DossoDepartment Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Marie-Anne MorrenDepartment of Dermatology, Pediatric Dermatology Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Lionel FontaoDepartment of Laboratory Medicine and Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland.
Laura BruschiDepartment of Dermatology, Pediatric Dermatology Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
François GorostidiDepartment of Surgery, Clinic of Otolaryngology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Thomas FerryDepartment Mother-Woman-Child, Clinic of Pediatric Intensive Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Emmanuella GuenovaDepartment of Dermatology, Pediatric Dermatology Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Céline J Fischer FumeauxDepartment Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Sébastien JoyeDepartment Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeonatal linear immunoglobulin A (IgA) bullous dermatosis (NLABD) is a rare, life-threatening, mucocutaneous bullous disorder. The pathogenesis and optimal treatment remain poorly defined and raise critical clinical challenges. CASE PRESENTATION: We present a case of a full-term female infant with severe cutaneous and respiratory symptoms due to NLABD. Diagnosis was confirmed by immunofluorescence on the infant's skin biopsy, while IgAs directed against the basement membrane of the skin and mucosa were identified in the mother's milk. The infant fully recovered after nearly 8 weeks of intensive multidisciplinary care, including non-invasive ventilation, nutritional support, wound care, systemic corticoid treatment, and breastfeeding discontinuation.

conclusionThis case underscores the importance of timely adequate diagnosis and management of this rare and serious condition. Moreover, it adds novel evidence documenting the presence of pathogenic IgAs in breastmilk.

introductionNeonatal linear immunoglobulin A (IgA) bullous dermatosis (NLABD) is a rare, life-threatening, mucocutaneous bullous disorder. The pathogenesis and optimal treatment remain poorly defined and raise critical clinical challenges. CASE PRESENTATION: We present a case of a full-term female infant with severe cutaneous and respiratory symptoms due to NLABD. Diagnosis was confirmed by immunofluorescence on the infant's skin biopsy, while IgAs directed against the basement membrane of the skin and mucosa were identified in the mother's milk. The infant fully recovered after nearly 8 weeks of intensive multidisciplinary care, including non-invasive ventilation, nutritional support, wound care, systemic corticoid treatment, and breastfeeding discontinuation.

conclusionThis case underscores the importance of timely adequate diagnosis and management of this rare and serious condition. Moreover, it adds novel evidence documenting the presence of pathogenic IgAs in breastmilk.

Indexed as

Breast FeedingImmunoglobulin ALinear IgA Bullous DermatosisMilk, HumanBiopsyFemaleHumansInfant, NewbornSkinTreatment OutcomeImmunoglobulin ABlisterBreastmilkCase reportCorticosteroidsImmunoglobulin A

Identifiers

PMID39278203
PMCPMC11809513

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