ArticleJournal of neuroimmunology2024
Fluorescence-detection size-exclusion chromatography specifically detects autoantibodies targeting the ganglionic acetylcholine receptor in patients with autoimmune autonomic ganglionopathy.
Leah Baxter, Steven Hopkins, Kevin C O'Connor, Minh C Pham, Richard J Nowak, Nancy L Monson, Kyle Blackburn, Ryan E Hibbs, Steven Vernino, Colleen M Noviello
Abstract read
In one paragraphArticle in Journal of neuroimmunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Leah BaxterDepartment of Neurobiology, University of California San Diego, United States.
Steven HopkinsDepartment of Neurology, University of Texas Southwestern Medical Center, United States.
Kevin C O'ConnorDepartment of Neurology, Yale University School of Medicine, United States; Department of Immunobiology, Yale University School of Medicine, United States.
Minh C PhamDepartment of Neurology, Yale University School of Medicine, United States.
Richard J NowakDepartment of Immunobiology, Yale University School of Medicine, United States.
Nancy L MonsonDepartment of Neurology, University of Texas Southwestern Medical Center, United States.
Kyle BlackburnDepartment of Neurology, University of Texas Southwestern Medical Center, United States.
Ryan E HibbsDepartment of Neurobiology, University of California San Diego, United States; Department of Pharmacology, University of California San Diego, United States.
Steven VerninoDepartment of Neurology, University of Texas Southwestern Medical Center, United States.
Colleen M NovielloDepartment of Neurobiology, University of California San Diego, United States. Electronic address: conoviello@ucsd.edu.
Funding
UT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3MMechanisms of autoimmunity in myasthenia gravisR01AI114780 · NIAID · YALE UNIVERSITY · PI Kevin C O'Connor · 2016 to 2026
$4.7MContribution of plasmablasts in the conversion of transverse myelitis to multiple sclerosisR01NS102417 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI MONSON, NANCY L · 2018 to 2022
$2.8MStructural mechanisms of autoimmune diseases targeting cys-loop receptorsR01NS130831 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ryan E Hibbs, NANCY L MONSON · 2023 to 2026
$2.5MImmune Profiling of EncephalitisR21NS098229 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI MONSON, NANCY L, VENKATESAN, ARUN · 2016 to 2017
$461kMechanisms of autoantibody production in myasthenia gravisR56AI114780 · NIAID · YALE UNIVERSITY · PI O'CONNOR, KEVIN C · 2015 to 2015
$416kNCATS NIH HHS UL1 TR003163NIAID NIH HHS R01 AI114780NIAID NIH HHS R56 AI114780NINDS NIH HHS R01 NS102417NINDS NIH HHS R01 NS130831NINDS NIH HHS R21 NS098229
6 · The paper itselfAbstract
Autoimmune autonomic ganglionopathy (AAG) is a rare disease wherein autoantibodies target the ganglionic acetylcholine receptor (gAChR). Current diagnosis in the United States depends upon clinical symptoms and positive autoantibody detection using a radioimmunoprecipitation assay (RIA). Here we offer a proof-of-principle study on an alternative method, fluorescence-detection size-exclusion-chromatography (FSEC). We show FSEC can detect autoantibodies against gAChR from patient sera but not healthy controls or samples from other autoimmune diseases. We compare FSEC to RIA and find good correlation. We discuss potential advantages of using FSEC as an alternative or as a first-step diagnostic prior to pursuing existing methodologies.
Indexed as
AutoantibodiesAutoimmune Diseases of the Nervous SystemChromatography, GelGanglia, AutonomicReceptors, CholinergicAdultAutonomic Nervous System DiseasesFemaleHumansMaleMiddle AgedAutoantibodiesReceptors, CholinergicAcetylcholine receptorAutonomicDetectionFSECMembrane proteinNeuronal
Identifiers
PMID39277987
PMCPMC12219111
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