Evidence map›Paper›PMID 39277961›Full record

ArticleNuclear medicine and biology

Automation of simplified two-step radiolabeling via ditosylate synthon for

Shihong Li, Alexander Schmitz, Yu-Ting Lu, Rammyani Pal, Swarbhanu Sarkar, Mark A Sellmyer, Robert H Mach, Hsiaoju Lee

Abstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shihong LiDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Alexander SchmitzDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Yu-Ting LuDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Rammyani PalDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Swarbhanu SarkarDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Mark A SellmyerDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Robert H MachDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA.
Hsiaoju LeeDepartment of Radiology, University of Pennsylvania; Philadelphia, PA, USA. Electronic address: leehsi@pennmedicine.upenn.edu.

Funding

Optimizing the synthesis of[18F]FTMP for commercial distributionR41EB034141 · NIBIB · VELLUM BIOSCIENCES LLC · PI SELLMYER, MARK A · 2023 to 2023
$300k
NIBIB NIH HHS R41 EB034141
6 · The paper itself

Abstract

Direct fluorination of a tosylate or mesylate precursor has been a wide-spread and reliable way for radio-fluorination. This approach can be difficult to achieve when the precursor cannot be easily obtained or is chemically unstable. A possible alternative method is to radiolabel ethylene ditosylate or 1,3-propanediol di-p-tosylate to form a radiofluorinated synthon. Here we present the automation of a simplified and reliable approach for the two-step fluorination using [

Indexed as

AutomationFluorine RadioisotopesIsotope LabelingRadioactive TracersRadiochemistryTrimethoprimFluorine-18Fluorine RadioisotopesRadioactive TracersTrimethoprimAllinOneAutomationPETRadiotracerTwo-step fluorination

Identifiers

PMID39277961
PMCPMC11714026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.