Evidence map›Paper›PMID 39277840›Full record

SynthesisEndocrine2024

Increased prevalence of negative pregnancy and fetal outcomes in women with primary adrenal insufficiency. A systematic review and meta-analysis.

Georgia Ilia, George Paltoglou, Christos Chatzakis, Panagiotis Christopoulos, Maria Tzitiridou-Chatzopoulou, George Mastorakos

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Georgia IliaUnit of Endocrinology, Diabetes Mellitus and Metabolism, "Aretaieion" Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece. ilia.m.georgia@gmail.com.
George PaltoglouUnit of Endocrinology, Diabetes Mellitus and Metabolism, "Aretaieion" Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Christos ChatzakisSecond Department of Obstetrics and Gynecology, School of Medicine, "Aristotle" University of Thessaloniki, Thessaloniki, Greece.
Panagiotis ChristopoulosSecond Department of Obstetrics and Gynecology, "Aretaieion" Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Maria Tzitiridou-ChatzopoulouDepartment of Midwifery, School of Healthcare Sciences, University of Western Macedonia, Ptolemaida, Greece.
George MastorakosUnit of Endocrinology, Diabetes Mellitus and Metabolism, "Aretaieion" Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal primary adrenal insufficiency (PAI) during pregnancy, due to either Addison disease (AD) or congenital adrenal hyperplasia (CAH), is rare. Only few studies have examined the subsequent important outcomes of maternal glucocorticoid and mineralocorticoid deficiencies during pregnancy upon the fetus and the neonate. Therefore, this systematic review and meta-analysis evaluated the impact of these deficiencies, with data from PubMed/Medline, Cochrane/CENTRAL, and Google Scholar. A total of 31 studies were included for qualitative analysis and 11 for quantitative analysis. Studies examining the prevalence of spontaneous abortion, preterm birth, the occurrence of small for gestational age (SGA) neonates, as well as the neonatal birth weight were included. The systematic review revealed a substantial number of spontaneous abortions, preterm births and SGA neonates in pregnant women with PAI. The meta-analysis showed a mean spontaneous abortion prevalence of 18%, 18% and 17% in women with PAI, AD or CAH, respectively. The mean preterm birth prevalence was 11% when women with AD or CAH were analyzed together, and 13% and 9% in women with AD or CAH, respectively, when these women were analyzed separately. The mean prevalence of SGA neonates was 8% when women with AD or CAH were analyzed together, and 5% and 10% in women with AD or CAH, respectively, when these women were analyzed separately. The mean fetal birth weight was within normalcy in all women with PAI, as well as in women with AD or CAH. In conclusion the executed systematic review of 31 studies followed by a meta-analysis of 11 studies in pregnant women with PAI has shown a greater prevalence of pregnancies with negative outcome (spontaneous abortion, preterm birth) and of negative fetal outcome (SGA) in women with either AD or CAH, as compared to control pregnant women.

Indexed as

Pregnancy ComplicationsPregnancy OutcomePremature BirthAbortion, SpontaneousAddison DiseaseAdrenal Hyperplasia, CongenitalFemaleHumansInfant, NewbornInfant, Small for Gestational AgePregnancyPrevalenceAddison diseaseCongenital adrenal hyperplasiaFetusNeonatePregnancyPrimary adrenal insufficiency

Identifiers

PMID39277840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.