Evidence map›Paper›PMID 39277738›Full record

ArticleVirology journal2024

The protective role of Mertk in JEV-induced encephalitis by maintaining the integrity of blood-brain barrier.

Chuanyu Luo, Mengyuan Li, Peiyu Bian, Jiali Yang, Xiamei Liao, Yangchao Dong, Chuantao Ye, Fanglin Zhang, Xin Lv, Qianqian Zhang and 1 more

Abstract read
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chuanyu Luo *Department of Clinical Laboratory, Norinco General Hospital, Xi'an, 710065, China.
Mengyuan Li *Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Peiyu BianDepartment of Geriatrics, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
Jiali YangDepartment of Cell Biology, National Translational Science Center for Molecular Medicine, Air Force Medical University, Xi'an, 710032, China.
Xiamei LiaoDepartment of Microbiology and Pathogen Biology, School of Basic Medical Sciences, Air Force Medical University, Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China.
Yangchao DongDepartment of Microbiology and Pathogen Biology, School of Basic Medical Sciences, Air Force Medical University, Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China.
Chuantao YeDepartment of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, 710032, China.
Fanglin ZhangDepartment of Microbiology and Pathogen Biology, School of Basic Medical Sciences, Air Force Medical University, Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China.
Xin LvDepartment of Microbiology and Pathogen Biology, School of Basic Medical Sciences, Air Force Medical University, Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China. luxin@fmmu.edu.cn.
Qianqian ZhangDepartment of Microbiology, Medical College, Yan'an University, Yan'an, 716000, China. zhangqianyd@163.com.
Yingfeng LeiDepartment of Microbiology and Pathogen Biology, School of Basic Medical Sciences, Air Force Medical University, Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China. yflei@fmmu.edu.cn.

Funding

National Natural Science Foundation of China 81871697
6 · The paper itself

Abstract

Japanese encephalitis is an acute infectious disease of the central nervous system caused by neurotropic Japanese encephalitis virus (JEV). As a member of TAM (Tyro3, Axl and Mertk) family, Mertk has involved in multiple biological processes by engaging with its bridging ligands Gas6 and Protein S, including invasion of pathogens, phagocytosis of apoptotic cells, inflammatory response regulation, and the maintenance of blood brain barrier (BBB) integrity. However, its role in encephalitis caused by JEV infection has not been studied in detail. Here, we found that Mertk

Indexed as

Blood-Brain Barrierc-Mer Tyrosine KinaseEncephalitis, JapaneseEncephalitis Virus, JapaneseAnimalsBrainCytokinesDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutViral Loadc-Mer Tyrosine KinaseCytokinesMertk protein, mouseBlood–brain barrierEncephalitisJapanese encephalitis virusMertkTAM receptors

Identifiers

PMID39277738
PMCPMC11401310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.