Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Urikhan SanzhaevaDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
Helen Boyd-PrattClinical Translational Sciences Institute, West Virginia University School of Medicine, Morgantown, WV, USA.
Philip T R BenderRockefeller Neuroscience Institute and Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA.
Thamaraiselvi SaravananDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
Scott B RhodesDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
Tongju GuanDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
Neil BillingtonDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.ORCID 0000-0003-2306-0228
Shannon E BoyeDivision of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
Christopher L CunninghamPittsburgh Hearing Research Center, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9619-4190
Charles T AndersonRockefeller Neuroscience Institute and Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA.ORCID 0000-0003-3353-0182
Visvanathan RamamurthyDepartment of Biochemistry and Molecular Medicine, West Virginia University School of Medicine, Morgantown, WV, USA. ramamurthyv@hsc.wvu.edu.ORCID 0000-0003-0289-3685
Funding
VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Shian Liu · 2022 to 2026
$13.9M
Engineering AAV for safe and efficient gene delivery to the human retinaR01EY024280 · NEI · UNIVERSITY OF FLORIDA · PI Shannon Elizabeth Boye · 2014 to 2026
$7.5M
Importance of Small GTPases in Photoreceptor FunctionR01EY028035 · NEI · WEST VIRGINIA UNIVERSITY · PI Visvanathan Ramamurthy · 2017 to 2026
$3.2M
The effects of synaptically released zinc on neuronal processing and brain functionR35GM138023 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CHARLES ANDERSON · 2020 to 2026
$3.2M
Research Training Program in Behavioral and Biomedical SciencesT32GM132494 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries, Kevin T Larkin · 2019 to 2026
$2.8M
Cell and Molecular Biology Training Program at West Virginia UniversityT32GM133369 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Zoica Cerasela Dinu, MICHAEL D SCHALLER · 2019 to 2026
$2.0M
Biosynthesis and trafficking of phosphodiesterase in the retinal photoreceptorsR01EY031346 · NEI · WEST VIRGINIA UNIVERSITY · PI RAMAMURTHY, VISVANATHAN · 2020 to 2024
$1.9M
Processing and localization of the mechanotransduction channel subunit TMC1R01DC021835 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUNNINGHAM, CHRISTOPHER L · 2024 to 2024
$696k
Mechanisms of Protein Assembly and Transport in Hair CellsR21DC019195 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CUNNINGHAM, CHRISTOPHER L · 2021 to 2023
$477k
NEI NIH HHS R01 EY024280NEI NIH HHS R01 EY028035NEI NIH HHS R01 EY031346NIDCD NIH HHS R01 DC021835NIDCD NIH HHS R21 DC019195NIGMS NIH HHS P20 GM144230NIGMS NIH HHS R35 GM138023NIGMS NIH HHS T32 GM132494NIGMS NIH HHS T32 GM133369U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY024280U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY028035U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY031346U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20GM144230U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM138023U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM132494U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM133369
6 · The paper itself
Abstract
Microtubules are essential for various cellular processes. The functional diversity of microtubules is attributed to the incorporation of various α- and β-tubulin isotypes encoded by different genes. In this work, we investigated the functional role of β4B-tubulin isotype (TUBB4B) in hearing and vision as mutations in TUBB4B are associated with sensorineural disease. Using a Tubb4b knockout mouse model, our findings demonstrate that TUBB4B is essential for hearing. Mice lacking TUBB4B are profoundly deaf due to defects in the inner and middle ear. Specifically, in the inner ear, the absence of TUBB4B lead to disorganized and reduced densities of microtubules in pillar cells, suggesting a critical role for TUBB4B in providing mechanical support for auditory transmission. In the middle ear, Tubb4b
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development. · full record | OpenQuestion