Evidence map›Paper›PMID 39277598›Full record

ArticleNature communications2024

Evaluating the risk of data loss due to particle radiation damage in a DNA data storage system.

Christopher N Takahashi, David P Ward, Carlo Cazzaniga, Christopher Frost, Paolo Rech, Kumkum Ganguly, Sean Blanchard, Steve Wender, Bichlien H Nguyen, Jake A Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christopher N TakahashiPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.
David P WardPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.
Carlo CazzanigaScience and Technology Facilities Council, Swindon, UK.
Christopher FrostScience and Technology Facilities Council, Swindon, UK.
Paolo RechUniversity of Trento, Trento, Italy.
Kumkum GangulyLos Alamos National Laboratory, Los Alamos, NM, USA.
Sean BlanchardLos Alamos National Laboratory, Los Alamos, NM, USA.
Steve WenderLos Alamos National Laboratory, Los Alamos, NM, USA.
Bichlien H NguyenPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. bnguy@microsoft.com.ORCID 0000-0001-5870-4914
Jake A SmithPaul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. jakesmith@microsoft.com.ORCID 0000-0003-0412-1312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA data storage is a potential alternative to magnetic tape for archival storage purposes, promising substantial gains in information density. Critical to the success of DNA as a storage media is an understanding of the role of environmental factors on the longevity of the stored information. In this paper, we evaluate the effect of exposure to ionizing particle radiation, a cause of data loss in traditional magnetic media, on the longevity of data in DNA data storage pools. We develop a mass action kinetics model to estimate the rate of damage accumulation in DNA strands due to neutron interactions with both nucleotides and residual water molecules, then utilize the model to evaluate the effect several design parameters of a typical DNA data storage scheme have on expected data longevity. Finally, we experimentally validate our model by exposing dried DNA samples to different levels of neutron irradiation and analyzing the resulting error profile. Our results show that particle radiation is not a significant contributor to data loss in DNA data storage pools under typical storage conditions.

Indexed as

DNADNA DamageInformation Storage and RetrievalKineticsNeutronsRadiation, IonizingDNA

Identifiers

PMID39277598
PMCPMC11401870

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.