Evidence map›Paper›PMID 39277590›Full record

ArticleNature communications2024

Longitudinal genomic analysis of Neisseria gonorrhoeae transmission dynamics in Australia.

Mona L Taouk, George Taiaroa, Sebastian Duchene, Soo Jen Low, Charlie K Higgs, Darren Y J Lee, Shivani Pasricha, Nasra Higgins, Danielle J Ingle, Benjamin P Howden and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Inferring Sexual Network Bridging Using Genomics: A Simulation Study.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Observational
  5. Article
  6. Open forum infectious diseases · 2026
    Article
  7. Genome analysis ofMicrobial genomics · 2025
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mona L TaoukDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0003-3820-5338
George TaiaroaDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Sebastian DucheneDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0002-2863-0907
Soo Jen LowDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0002-5129-9175
Charlie K HiggsDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Darren Y J LeeDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Shivani PasrichaDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Nasra HigginsVictorian Department of Health, Melbourne, VIC, Australia.
Danielle J IngleDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0003-0707-6537
Benjamin P HowdenDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.ORCID 0000-0003-0237-1473
Marcus Y ChenMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
Eric P F ChowMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.ORCID 0000-0003-1766-0657
Deborah A WilliamsonDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. deborah.williamson@unimelb.edu.au.ORCID 0000-0001-7363-6665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N. gonorrhoeae, which causes the sexually transmissible infection gonorrhoea, remains a significant public health threat globally, with challenges posed by increasing transmission and antimicrobial resistance (AMR). The COVID-19 pandemic introduced exceptional circumstances into communicable disease control, impacting the transmission of gonorrhoea and other infectious diseases. Through phylogenomic and phylodynamic analysis of 5881 N. gonorrhoeae genomes from Australia, we investigated N. gonorrhoeae transmission over five years, including a time period during the COVID-19 pandemic. Using a novel cgMLST-based genetic threshold, we demonstrate persistence of large N. gonorrhoeae genomic clusters over several years, with some persistent clusters associated with heterosexual transmission. We observed a decline in both N. gonorrhoeae transmission and genomic diversity during the COVID-19 pandemic, suggestive of an evolutionary bottleneck. The longitudinal, occult transmission of N. gonorrhoeae over many years further highlights the urgent need for improved diagnostic, treatment, and prevention strategies for gonorrhoea.

Indexed as

COVID-19Genome, BacterialGenomicsGonorrheaNeisseria gonorrhoeaePhylogenyAdultAustraliaFemaleHumansLongitudinal StudiesMaleSARS-CoV-2Young Adult

Identifiers

PMID39277590
PMCPMC11401900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.