Evidence map›Paper›PMID 39276720›Full record

ArticleParkinsonism & related disorders2024

Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism.

Toji Miyagawa, Cynthia Vernon, Scott A Przybelski, Paul H Min, Julie A Fields, Bradford C Dickerson, Dennis W Dickson, Kejal Kantarci, Val J Lowe, Zbigniew K Wszolek and 1 more

Abstract readLetter
In one paragraph

Article in Parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Miyagawa.Toji@mayo.edu.
Cynthia VernonDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Scott A PrzybelskiDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Paul H MinDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dennis W DicksonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Zbigniew K WszolekDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
NIA NIH HHS P30 AG062677NIA NIH HHS U19 AG063911NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

Our research found out, from

Indexed as

Dopamine Plasma Membrane Transport ProteinsFrontotemporal Lobar DegenerationMutationProdromal Symptomstau ProteinsTomography, Emission-Computed, Single-PhotonAgedCorpus StriatumFemaleHumansMaleMiddle AgedParkinsonian DisordersTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamine Plasma Membrane Transport ProteinsMAPT protein, humantau ProteinsTropanes123I-FP-CIT SPECTDaTQUANTFamilial FTLDMAPT N279KParkinsonism

Identifiers

PMID39276720
PMCPMC13370675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.