Evidence map›Paper›PMID 39276613›Full record

ArticleComputers in biology and medicine2024

Effect of upper body venoarterial ECMO on systemic hemodynamics and oxygenation: A computational study.

Hamed Moradi, Raghu R Seethala, Elazer R Edelman, Steven P Keller, Farhad R Nezami

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In one paragraph

Article in Computers in biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hamed MoradiDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
Raghu R SeethalaDivision of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Elazer R EdelmanInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Steven P KellerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA. Electronic address: steven.keller@jhmi.edu.
Farhad R NezamiDivision of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Personalized lesion modification optimizes atherosclerosis interventionR01HL161069 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 2022 to 2025
$2.8M
Functional restoration of ventriculo-arterial coupling in cardiogenic shock via dual mechanical supportK08HL143342 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KELLER, STEVEN PAUL · 2018 to 2023
$853k
NHLBI NIH HHS K08 HL143342NHLBI NIH HHS R01 HL161069
6 · The paper itself

Abstract

backgroundThis study seeks to quantify the effects of upper body veno-arterial extracorporeal membrane oxygenation (VA ECMO) on the anatomical distribution of oxygen delivery in the setting of hypoxic respiratory failure and provide new insights that will guide clinical use of this support strategy to bridge patients to lung transplant.

methodsEmploying a patient-specific vascular geometry and a quantitative model of oxygen transport, computational simulations were performed to determine hemodynamics and oxygen delivery in the ascending and descending aorta, left and right coronary arteries, and great vessels during upper body VA ECMO support. Oxygen content in ECMO circuit blood flow was varied while considering different degrees of lung failure severity. Using lumped parameter models to dynamically apply perfusion boundary conditions, hemodynamic parameters and oxygen content were analyzed to assess the effect of ECMO supply titration.

resultsThe results emphasize the importance of anatomical distribution for tissue oxygen delivery in severe lung failure, with ECMO-derived flow primarily augmenting oxygen content in specific vascular beds. They also demonstrate that although cannulating the subclavian artery can enhance cerebral oxygen delivery, its ability to ensure sufficient oxygen delivery to the coronary circulation seems to be comparatively restricted.

conclusionsThe oxygen delivery to a specific vascular area is primarily determined by the oxygen content in the source of perfusion. Caution is advised with upper body VA ECMO for patients with hypoxic respiratory failure and right ventricle dysfunction, due to potential coronary ischemia. Management of these patients is challenging due to disease progression and organ availability uncertainties.

Indexed as

Extracorporeal Membrane OxygenationHemodynamicsModels, CardiovascularOxygenComputer SimulationHumansRespiratory InsufficiencyOxygen

Identifiers

PMID39276613
PMCPMC11584320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.