Evidence map›Paper›PMID 39276599›Full record

ArticleMultiple sclerosis and related disorders2024

Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study.

Chen Hu, Eleni S Vasileiou, Amber Salter, Ruth Ann Marrie, Kaarina Kowalec, Kathryn C Fitzgerald

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In one paragraph

Article in Multiple sclerosis and related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chen HuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Eleni S VasileiouDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Amber SalterDepartment of Neurology, University of Texas Southwestern, Dallas, TX, United States.
Ruth Ann MarrieDepartment of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Kaarina KowalecCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden.
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: fitzgerald@jhmi.edu.

Funding

Circadian Rhythms and Sleep, Structural Neuroimaging and Depression in People with Multiple SclerosisK01MH121582 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FITZGERALD, KATHRYN C. · 2019 to 2022
$675k
NIMH NIH HHS K01 MH121582
6 · The paper itself

Abstract

backgroundDepression is common and phenotypically heterogenous in multiple sclerosis (MS). MS may increase risk of some but not all affective symptoms or certain symptoms may predispose individuals to higher MS risk.

objectiveTo assess the existence and direction of causality between distinct depressive symptoms and MS using two-sample Mendelian randomization (MR).

methodsUsing summary data from genome-wide association studies, we selected genetic instrument variables (IV) for MS (n = 115,776) and IVs for depressive symptoms (average n = 117,713): anhedonia, altered appetite, concentration, depressed mood, fatigue, inadequacy, psychomotor changes, sleeping problems and suicidality. We performed two-sample MR in either direction using inverse-variance models. Sensitivity analyses included weighted-median and MR-Egger regression. Obesity is a known risk factor for MS and depression; we adjusted for body mass index in multivariable-MR.

resultsGenetic liability to MS was associated with anhedonia (IVW estimate per 10

conclusionsGenetic susceptibility to MS was associated with anhedonia, concentration, and psychomotor-related symptoms, suggesting a specific phenotype of depression in MS.

Indexed as

DepressionGenome-Wide Association StudyMendelian Randomization AnalysisMultiple SclerosisAnhedoniaHumansDepressive symptomsMendelian randomizationMultiple sclerosis

Identifiers

PMID39276599
PMCPMC11527576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.