Evidence map›Paper›PMID 39276435›Full record

ArticleJournal of the mechanical behavior of biomedical materials2024

Mechanical investigation of a Tandem embolization-visualization system for minimally invasive procedures.

Peng Chen, George Varghese P J, Keren Zhao, Jingjie Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peng ChenDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA, 27695.
George Varghese P JDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA, 27695.
Keren ZhaoDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA, 27695.
Jingjie HuDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA, 27695. Electronic address: jhu35@ncsu.edu.

Funding

Integrated experimental and computational approach for accurate patient-specific vascular embolizationR21AG083692 · NIA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ARZANI, AMIRHOSSEIN, HU, JINGJIE · 2023 to 2025
$581k
Developing Therapeutic Gel Embolic Agents for Arteriovenous Malformation EmbolizationR03EB033633 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HU, JINGJIE · 2023 to 2024
$144k
NIA NIH HHS R21 AG083692NIBIB NIH HHS R03 EB033633
6 · The paper itself

Abstract

Transcatheter arterial embolization is a minimally invasive intervention process in which the blood supply to a tumor or an abnormal area of tissue is blocked. One of the most commonly used embolic agents in clinics is microsphere (MS). In order to understand the flow behavior of microspheres in arteries, it is essential to study their mechanical properties systematically. In this work, calcium-alginate MSs with varying calcium concentrations were synthesized using a coaxial airflow method. Indocyanine green (ICG) was added as a fluorescent dye. The effect of ICG concentration change on microspheres was investigated by studying morphology, imageability, rheology, and swelling behavior. Then the effect of calcium chloride concentration change on microspheres was studied by conducting rheological tests, atomic force microscopy tests, hemolysis assay, and thrombogenicity assay. Results showed that microspheres with higher ICG concentrations have longer lasting fluorescence and lower storage modulus (G'). Higher concentrations of calcium chloride led to higher G', while the local Young's modulus obtained by AFM test was not significantly affected. The MSs with and without ICG showed good hemocompatibility and thrombogenicity.

Indexed as

Embolization, TherapeuticMechanical PhenomenaMicrospheresAlginatesAnimalsCalcium ChlorideHemolysisHumansIndocyanine GreenMaterials TestingMinimally Invasive Surgical ProceduresRheologyAlginatesCalcium ChlorideIndocyanine GreenCalcium-alginate microsphereEmbolic agentFluorescence imagingIndocyanine greenTranscatheter arterial embolizationTunable mechanical property

Identifiers

PMID39276435
PMCPMC11560564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.