Evidence map›Paper›PMID 39276264›Full record

ArticleNatural products and bioprospecting2024

Grewiifopenes A-K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.

Phanruethai Pailee, Paratchata Batsomboon, Wiriya Yaosanit, Theerawat Thananthaisong, Chulabhorn Mahidol, Poonsakdi Ploypradith, Nanthawan Reuk-Ngam, Panita Khlaychan, Supanna Techasakul, Somsak Ruchirawat and 1 more

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In one paragraph

Article in Natural products and bioprospecting, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Phanruethai PaileeLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Paratchata BatsomboonLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Wiriya YaosanitLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Theerawat ThananthaisongDepartment of National Parks, Wildlife and Plant Conservation, Forest Herbarium, Bangkok, 10900, Thailand.
Chulabhorn MahidolLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Poonsakdi PloypradithLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Nanthawan Reuk-NgamLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Panita KhlaychanLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Supanna TechasakulLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Somsak RuchirawatLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Vilailak PrachyawarakornLaboratory of Natural Products, Medicinal Chemistry and Organic Synthesis, Chulabhorn Research Institute, Bangkok, 10210, Thailand. vilailak@cri.or.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eleven novel clerodane-type diterpenoids, grewiifopenes A-K (1-4 and 12-18), along with nine known compounds (5-11, 19, and 20) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations. The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC

Indexed as

Antibacterial activityCasearia grewiifolia Vent.Clerodane diterpenoidsCytotoxic activitySalicaceae

Identifiers

PMID39276264
PMCPMC11401813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.