Evidence map›Paper›PMID 39276249›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Chemistry, biosynthesis, and theranostics of antioxidant flavonoids and polyphenolics of genus Rhododendron: an overview.

Amjad Hussain, Sajjad Azam, Rabia Maqsood, Riaz Anwar, Muhammad Sajid Hamid Akash, Hidayat Hussain, Daijie Wang, Muhammad Imran, Katarzyna Kotwica-Mojzych, Shoaib Khan and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Accumulation of Phenolic Compounds in Microshoot Cultures ofInternational journal of molecular sciences · 2025
    Article
  5. Molecules (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amjad HussainInstitute of Chemistry, University of Okara, Okara, 56300, Pakistan. amjadhussain@uo.edu.pk.
Sajjad AzamInstitute of Chemistry, University of Okara, Okara, 56300, Pakistan.
Rabia MaqsoodInstitute of Chemistry, University of Okara, Okara, 56300, Pakistan.
Riaz AnwarInstitute of Chemistry, University of Okara, Okara, 56300, Pakistan.
Muhammad Sajid Hamid AkashDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Hidayat HussainDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, D-06120, Halle (Saale), Germany.
Daijie WangSchool of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Muhammad ImranDepartment of Chemistry, Faculty of Science, Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.
Katarzyna Kotwica-MojzychChair of Fundamental Sciences, Department of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwillowska 11, 20-080, Lublin, Poland.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology (AUST), Havelian, Abbottabad, Pakistan.
Shabbir HussainDepartment of Chemistry, Karakoram International University (KIU), Gilgit, Gilgit-Baltistan, 15100, Pakistan.
Muhammad Adnan AyubDepartment of Chemistry, University of Sahiwal, Sahiwal, 54000, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genus Rhododendron is an ancient and most widely distributed genus of the family Ericaceae consisting of evergreen plant species that have been utilized as traditional medicine since a very long time for the treatment of various ailments including pain, asthma, inflammation, cold, and acute bronchitis. The chemistry of polyphenolics isolated from a number of species of the genus Rhododendron has been investigated. During the currently designed study, an in-depth study on the phytochemistry, natural distribution, biosynthesis, and pharmacological properties including their potential capability as free radical scavengers has been conducted. This work provides structural characteristics of phenolic compounds isolated from the species of Rhododendron with remarkable antioxidant potential. In addition, biosynthesis and theranostic study have also been encompassed with the aims to furnish a wide platform of valuable information for designing of new drug entities. The detailed information including names, structural features, origins, classification, biosynthetic pathways, theranostics, and pharmacological effects of about 171 phenolics and flavonoids isolated from the 36 plant species of the genus Rhododendron with the antioxidant potential has been covered in this manuscript. This study demonstrated that species of Rhododendron genus have excellent antioxidant activities and great potential as a source for natural health products. This comprehensive review might serve as a foundation for more investigation into the Rhododendron genus.

Indexed as

AntioxidantsFlavonoidsPolyphenolsRhododendronAnimalsHumansPlant ExtractsTheranostic NanomedicineAntioxidantsFlavonoidsPlant ExtractsPolyphenolsAnti-oxidantBiosynthesisPhytochemistryRhododendronTheranostics

Identifiers

PMID39276249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.