Evidence map›Paper›PMID 39276201›Full record

ArticleImmunologic research2024

Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy.

Chenqi Xu, Kunming Pan, Jie Li, Yang Li, Shi Jin, Yiqin Shi, Jie Teng, Xiaoqiang Ding, Xialian Xu, Hong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenqi Xu *Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China.
Kunming Pan *Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jie LiDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China.
Yang LiDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China.
Shi JinDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China.
Yiqin ShiDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China.
Jie TengDepartment of Nephrology, Zhongshan Hospital (Xiamen), Fudan University, Nephrology Clinical Quality Control Center of Xiamen, Xiamen, 361015, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney Disease and Blood Purification, Shanghai Institute of Kidney and Dialysis, Hemodialysis Quality Control Center of Shanghai, Shanghai, 200032, China.
Xialian XuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China. xu.xialian@zs-hospital.sh.cn.
Hong LiuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai Medical Center of Kidney Disease, Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai Institute of Kidney and Dialysis, Shanghai, 200032, China. liu.hong@zs-hospital.sh.cn.

Funding

China International Medical Foundation No.Z-2021-46-2101National Natural Science Foundation of China 82000706National Natural Science Foundation of China 82204520Natural Science Foundation of Shanghai 23ZR1411200Shanghai Clinical Research Center for Kidney Disease 22MC1940100Shanghai Municipal Key Clinical Specialty shslczdzk02501Shanghai Pharmaceutical Association No.(2023)04The Chinese Pharmaceutical Association No.CPA-Z05-ZC-2023-003
6 · The paper itself

Abstract

This study aims to explore the relationship between serum soluble interleukin-2 receptor alpha (sIL-2Rα) levels and histologic features in immunoglobin A nephropathy (IgAN), and evaluate its predicting values on disease progression and remission status. IgAN patients were included retrospectively. Lee classification, Oxford classification and histological scoring were evaluated. Patients' estimated filtration rate (eGFR) and proteinuria remission status were collected during 6-month follow-up. Logistic regression was used to determine the risk factors and predicting value. Receiver operating characteristic (ROC) curve were used to determine the predicting value for outcome. One hundred seventy-two subjects were included in this study. Individuals in moderate-to-severe tubulointerstitial inflammatory cell infiltration group manifested with significantly elevated serum sIL-2Rα levels than those in non-to-mild group. Serum sIL-2Rα levels were positively correlated with infiltration scores. Serum sIL-2Rα was an independent risk factor for moderate-to-severe inflammatory cell infiltration [sIL-2Rα: OR 1.29 (1.015-1.640, p = 0.038)]. ROC curve analysis regarding predictive value for moderate-to-severe inflammatory cell infiltration of sIL-2Rα suggested area under curve was 0.859 (0.801-0.918, p = 0.000) when sIL-2Rα combined with eGFR < 60 mL/(min·1.73 m

Indexed as

Disease ProgressionGlomerulonephritis, IGAInterleukin-2 Receptor alpha SubunitAdultBiomarkersBiopsyFemaleGlomerular Filtration RateHumansKidneyMaleMiddle AgedPrognosisRetrospective StudiesROC CurveYoung AdultBiomarkersInterleukin-2 Receptor alpha SubunitImmunoglobin A nephropathySoluble interleukin-2 receptor alphaT cellTubulointerstitial inflammation

Identifiers

PMID39276201
PMCPMC11618199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.