Evidence map›Paper›PMID 39276155›Full record

ArticleJNCI cancer spectrum2024

Risk of anxiety disorders in men with prostate cancer: a national cohort study.

Casey Crump, Pär Stattin, James D Brooks, Jan Sundquist, Kristina Sundquist, Weiva Sieh

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Article in JNCI cancer spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Casey CrumpDepartments of Family and Community Medicine and of Epidemiology, The University of Texas Health Science Center, Houston, TX, USA.ORCID 0000-0002-2990-1166
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8306-0687
James D BrooksDepartment of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Jan SundquistCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0001-7228-5015
Kristina SundquistCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden.ORCID 0000-0001-8031-279X
Weiva SiehDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

Long-Term Mental Health Outcomes in Prostate Cancer Survivors and Their PartnersR01CA269553 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CRUMP, CASEY, SIEH, WEIVA · 2022 to 2025
$2.1M
NCI NIH HHS R01 CA269553Swedish Research Council
6 · The paper itself

Abstract

backgroundMen with prostate cancer (PC) may experience significant psychosocial distress from physical symptoms, treatment side effects, or fear of recurrence. However, little is known about the long-term risk of anxiety disorders in men with PC.

methodsA national cohort study was conducted of 180 189 men diagnosed with PC during 1998-2017 and 1 801 890 age-matched population-based control men in Sweden. Anxiety disorders were ascertained from nationwide outpatient and inpatient records through 2018. Cox regression was used to estimate hazard ratios (HRs) while adjusting for sociodemographic factors and prior psychiatric disorders. Subanalyses explored differences by PC treatment during 2005-2017.

resultsIn 7.8 million person-years of follow-up, 94 387 (5%) men were diagnosed with anxiety disorders. Men with high-risk PC had a nearly 2-fold higher risk of anxiety disorders than control men without PC (adjusted HR = 1.96, 95% CI = 1.87 to 2.05). This risk was highest in the first 3 months after PC diagnosis (adjusted HR = 2.99, 95% CI = 2.49 to 3.59) but remained significantly elevated 10 or more years later (adjusted HR = 1.53, 95% CI = 1.35 to 1.74). Those treated only with androgen deprivation therapy (ADT) had the highest risk of anxiety disorders (adjusted HR = 2.08, 95% CI = 1.93 to 2.25). Men with low- or intermediate-risk PC had a modestly increased risk (adjusted HR = 1.39, 95% CI = 1.34 to 1.44).

conclusionsIn this large national cohort, men with PC had substantially increased risk of anxiety disorders, especially those with high-risk PC and treated only with ADT. Men with PC need close monitoring for timely detection and treatment of anxiety symptoms, particularly shortly after PC diagnosis.

Indexed as

Anxiety DisordersProportional Hazards ModelsProstatic NeoplasmsAgedAged, 80 and overAndrogen AntagonistsCase-Control StudiesCohort StudiesHumansMaleMiddle AgedRisk FactorsSwedenTime FactorsAndrogen Antagonists

Identifiers

PMID39276155
PMCPMC11512143

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