Evidence map›Paper›PMID 39276058›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus: a two-sample bidirectional Mendelian randomization study].

W Zhong, W Li, Z Li, Q Wang, W Zhang

Abstract readEnglish Abstract
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

W ZhongDepartment of Pediatric Neurosurgery, Center of Neurosurgery, Zhujiang Hospital, Southern Medical University//Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration//The National Key Clinical Specialty//The Engineering Technology Research Center of Education Ministry of China, Guangzhou 510282, China.
W LiDepartment of Pediatric Neurosurgery, Center of Neurosurgery, Zhujiang Hospital, Southern Medical University//Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration//The National Key Clinical Specialty//The Engineering Technology Research Center of Education Ministry of China, Guangzhou 510282, China.
Z LiDepartment of Pediatric Neurosurgery, Center of Neurosurgery, Zhujiang Hospital, Southern Medical University//Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration//The National Key Clinical Specialty//The Engineering Technology Research Center of Education Ministry of China, Guangzhou 510282, China.
Q WangDepartment of Pediatric Neurosurgery, Center of Neurosurgery, Zhujiang Hospital, Southern Medical University//Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration//The National Key Clinical Specialty//The Engineering Technology Research Center of Education Ministry of China, Guangzhou 510282, China.
W ZhangDepartment of Pediatric Neurosurgery, Center of Neurosurgery, Zhujiang Hospital, Southern Medical University//Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration//The National Key Clinical Specialty//The Engineering Technology Research Center of Education Ministry of China, Guangzhou 510282, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus (iNPH) using two-sample bidirectional Mendelian randomization.

methodsThe exposure data including 8 sleep phenotypes used in this study were obtained from GWAS catalog, FinnGenR10 and MRCIEU GWAS. The outcome data for idiopathic normal-pressure hydrocephalus were obtained from FinnGen R10. We used the inverse-variance weighted (IVW) method to perform the principal analyses. Cochrane Q-statistics test was used to assess the heterogeneity and MR Egger‑intercept test performed to evaluate the pleiotropy for sensitivity analyses.

resultsIVW result showed that frequent daytime nap was associated with higher odds of iNPH (OR=3.3393, 95

conclusionThe frequency of daytime naps is causally associated with iNPH, and reducing the frequency of weekly daytime naps can reduce the risk of iNPH in the elderly population.

Indexed as

Hydrocephalus, Normal PressureMendelian Randomization AnalysisPhenotypeSleepGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk Factorsday napidiopathic normal pressure hydrocephalusMendelian randomizationsleep phenotype

Identifiers

PMID39276058
PMCPMC11378049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.