Evidence map›Paper›PMID 39276055›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Linarin inhibits microglia activation-mediated neuroinflammation and neuronal apoptosis in mouse spinal cord injury by inhibiting the TLR4/NF-κB pathway].

L Xiao, T Duan, Y Xia, Y Chen, Y Sun, Y Xu, L Xu, X Yan, J Hu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L XiaoDepartment of Rehabilitation Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
T DuanDepartment of Emergency Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y XiaDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y ChenDepartment of Rehabilitation Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y SunDepartment of Rehabilitation Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y XuDepartment of Histology and Embryology, College of Basic Medical Sciences, Bengbu Medical University, Bengbu 233030, China.
L XuDepartment of Rehabilitation Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
X YanDepartment of Rehabilitation Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
J HuAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the mechanism underlying the neuroprotective effect of linarin (LIN) against microglia activation-mediated inflammation and neuronal apoptosis following spinal cord injury (SCI).

methodsFifty C57BL/6J mice (8- 10 weeks old) were randomized to receive sham operation, SCI and linarin treatment at 12.5, 25, and 50 mg/kg following SCI (

resultsLinarin treatment significantly improved locomotor function (

conclusionThe neuroprotective effect of linarin is medicated by inhibition of microglia activation

Indexed as

ApoptosisMice, Inbred C57BLMicrogliaNF-kappa BSignal TransductionSpinal Cord InjuriesToll-Like Receptor 4AnimalsCoumarinsGlycosidesInflammationLipopolysaccharidesMiceNeuroinflammatory DiseasesNeuronsNeuroprotective AgentsCoumarinsGlycosideslinarinLipopolysaccharidesNeuroprotective AgentsNF-kappa BTlr4 protein, mouseToll-Like Receptor 4apoptosislinarinneuroinflammationspinal cord injuryTLR4/NF-κB

Identifiers

PMID39276055
PMCPMC11378057

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.