Evidence map›Paper›PMID 39276045›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Biological role of SPAG5 in the malignant proliferation of gastric cancer cells].

Y Pang, Y Liu, S Chen, J Zhang, J Zeng, Y Pan, J An

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Y PangMedical College, Qinghai University, Xining, 810001, China.
Y LiuMedical College, Qinghai University, Xining, 810001, China.
S ChenMedical College, Qinghai University, Xining, 810001, China.
J ZhangMedical College, Qinghai University, Xining, 810001, China.
J ZengMedical College, Qinghai University, Xining, 810001, China.
Y PanCancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
J AnMedical College, Qinghai University, Xining, 810001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the expression of SPAG5 in gastric cancer tissues and its regulatory roles in gastric cancer cell growth.

methodsTCGA analysis, immunohistochemistry, and immunofluorescence staining were used to analyze the expression patterns of SPAG5 and MKi67 in gastric cancer and adjacent tissues. In gastric cancer AGS and MGC803 cells, the effects of lentivirus-mediated SPAG5 knockdown on cell growth and apoptosis were evaluated using Celigo, MTT, clone formation assays and flow cytometry.

resultsProteinatlas and TCGA database analysis suggested that SPAG5 was highly expressed in gastric cancer, and Kaplan-Meier analysis and GEPIA analysis showed high expressions of SPAG 5 in lung adenocarcinoma, breast cancer, hepatocellular carcinoma, pancreatic carcinoma, cervical cancer and bladder carcinoma. Immunohistochemistry revealed that SPAG5 was highly expressed in gastric cancer tissues (

conclusionsThe expressions of SPAG5 and MKi67 are correlated in gastric cancer tissues, and SPAG5 knockdown inhibits the proliferation of gastric cancer cells. SPAG5 is associated with the prognosis of gastric cancer patients and may serve as a promising biomarker for gastric cancer.

Indexed as

ApoptosisCell ProliferationStomach NeoplasmsCell Cycle ProteinsCell Line, TumorHumansKi-67 AntigenCell Cycle ProteinsKi-67 AntigenMKI67 protein, humanSPAG5 protein, humancell proliferationgastric cancerMKi67SPAG5

Identifiers

PMID39276045
PMCPMC11378056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.