Evidence map›Paper›PMID 39276043›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Kuwanon G inhibits growth, migration and invasion of gastric cancer cells by regulating the PI3K/AKT/mTOR pathway].

Z Geng, J Yang, M Niu, X Liu, J Shi, Y Liu, X Yao, Y Zhang, X Zhang, J Hu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Z GengCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, China.
J YangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, China.
M NiuDepartment of Immunology, School of Laboratory Medicine, Bengbu Medical University, Bengbu 233000, China.
X LiuAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.
J ShiAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.
Y LiuAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.
X YaoAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.
Y ZhangAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.
X ZhangCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, China.
J HuAnhui Provincial Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu 233003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of kuwanon G (KG) on proliferation, apoptosis, migration and invasion of gastric cancer cells and the molecular mechanisms.

methodsThe effects of KG on proliferation and growth of gastric cancer cells were assessed with CCK-8 assay and cell clone formation assay, by observing tumor formation on the back of nude mice and using immunohistochemical analysis of Ki-67. The effect of KG on cell apoptosis was analyzed using Annexin V-FITC/PI apoptosis detection kit, Western blotting and TUNEL staining. The effects of KG on cell migration and invasion were detected using Transwell migration and invasion assay and Western blotting for matrix metalloproteinase (MMP). The role of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in KG-mediated regulation of gastric cancer cell proliferation, migration, and invasion was verified by Western blotting and rescue assay.

resultsKG significantly inhibited proliferation and reduced clone formation ability of gastric cancer cells in a concentration-dependent manner (

conclusionKG inhibits proliferation, migration and invasion and promotes apoptosis of gastric cancer cells at least in part by inhibiting the activation of the PI3K/AKT/mTOR pathway.

Indexed as

ApoptosisCell MovementCell ProliferationMice, NudePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionStomach NeoplasmsTOR Serine-Threonine KinasesAnimalsCaspase 3Cell Line, TumorHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceCaspase 3Matrix Metalloproteinase 2Matrix Metalloproteinase 9MTOR protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesgastric cancerkuwanon Gmalignant behaviorsPI3K/AKT/mTOR pathway

Identifiers

PMID39276043
PMCPMC11378037

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.