Evidence map›Paper›PMID 39275998›Full record

ArticleProtein science : a publication of the Protein Society2024

Mining unique cysteine synthetases and computational study on thoroughly eliminating feedback inhibition through tunnel engineering.

Shuai Xu, Zong-Lin Li, Zhi-Min Li, Hong-Lai Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shuai XuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Zong-Lin LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.ORCID 0000-0002-1729-9593
Zhi-Min LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Hong-Lai LiuSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Funding

National Natural Science Foundation of China 32171478Postdoctoral Fellowship Program of CPSF GZC20230799
6 · The paper itself

Abstract

L-cysteine is an essential component in pharmaceutical and agricultural industries, and synthetic biology has made strides in developing new metabolic pathways for its production, particularly in archaea with unique O-phosphoserine sulfhydrylases (OPSS) as key enzymes. In this study, we employed database mining to identify a highly catalytic activity OPSS from Acetobacterium sp. (AsOPSS). However, it was observed that the enzymatic activity of AsOPSS suffered significant feedback inhibition from the product L-cysteine, exhibiting an IC

Indexed as

CysteineCysteine SynthaseMolecular Dynamics SimulationBacterial ProteinsMolecular Docking SimulationProtein EngineeringBacterial ProteinsCysteineCysteine Synthasefeedback inhibitionL‐cysteineMD simulationO‐phosphoserine sulfhydrylasessynthetic biologytunnel engineering

Identifiers

PMID39275998
PMCPMC11400630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.