Evidence map›Paper›PMID 39275992›Full record

ReviewImmunological reviews2024

Maternal influences on offspring food allergy.

Hwa Yeong Lee, Tanuza Nazmul, Jinggang Lan, Michiko K Oyoshi

Abstract readReview
In one paragraph

Review in Immunological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hwa Yeong LeeMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Tanuza NazmulMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Jinggang LanMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Michiko K OyoshiMucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.ORCID 0000-0002-0931-3949

Funding

Maternal influence on offspring food allergyR01AI172938 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI OYOSHI, MICHIKO · 2022 to 2025
$2.2M
Induction of food allergen-specific neonatal tolerance through breast milkR01AI142872 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI OYOSHI, MICHIKO · 2019 to 2021
$2.0M
Role of maternal Treg cells in the induction of neonatal toleranceR21AI151591 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI OYOSHI, MICHIKO · 2021 to 2022
$462k
NIAID NIH HHS R01 AI142872NIAID NIH HHS R01 AI172938NIAID NIH HHS R21 AI151591
6 · The paper itself

Abstract

The prevalence of allergies has been globally escalating. While allergies could appear at any age, they often develop in early life. However, the significant knowledge gap in the field is the mechanisms by which allergies affect certain people but not others. Investigating early factors and events in neonatal life that have a lasting impact on determining the susceptibilities of children to develop allergies is a significant area of the investigation as it promotes the understanding of neonatal immune system that mediates tolerance versus allergies. This review focuses on the research over the recent 10 years regarding the potential maternal factors that influence offspring allergies with a view to food allergy, a potentially life-threatening cause of anaphylaxis. The role of breast milk, maternal diet, maternal antibodies, and microbiota that have been suggested as key maternal factors regulating offspring allergies are discussed here. We also suggest future research area to expand our knowledge of maternal-offspring interactions on the pathogenesis of food allergy.

Indexed as

Food HypersensitivityAllergensAnaphylaxisAnimalsFemaleHumansImmune ToleranceInfant, NewbornMaternal ExposureMicrobiotaMilk, HumanPregnancyPrenatal Exposure Delayed EffectsAllergensantibodiesbreast milkfood allergyimmune complex microbiota

Identifiers

PMID39275992
PMCPMC11867100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.