Evidence map›Paper›PMID 39275884›Full record

ArticleBioFactors (Oxford, England)

Cannabinol modulates the endocannabinoid system and shows TRPV1-mediated anti-inflammatory properties in human keratinocytes.

Camilla Di Meo, Daniel Tortolani, Sara Standoli, Francesca Ciaramellano, Beatrice Clotilde Angelucci, Annamaria Tisi, Salam Kadhim, Eric Hsu, Cinzia Rapino, Mauro Maccarrone

Abstract read
In one paragraph

Article in BioFactors (Oxford, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Exploring Cannabinoid Effects Using Zebrafish (International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Camilla Di MeoDepartment of Veterinary Medicine, University of Teramo, Teramo, Italy.ORCID https://orcid.org/0000-0003-2045-3114
Daniel TortolaniDepartment of Veterinary Medicine, University of Teramo, Teramo, Italy.ORCID https://orcid.org/0000-0002-6704-9023
Sara StandoliDepartment of Veterinary Medicine, University of Teramo, Teramo, Italy.
Francesca CiaramellanoEuropean Center for Brain Research (CERC), Santa Lucia Foundation IRCCS, Rome, Italy.
Beatrice Clotilde AngelucciDepartment of Veterinary Medicine, University of Teramo, Teramo, Italy.
Annamaria TisiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Salam KadhimInMed Pharmaceuticals Inc., Vancouver, BC, Canada.
Eric HsuInMed Pharmaceuticals Inc., Vancouver, BC, Canada.
Cinzia RapinoDepartment of Veterinary Medicine, University of Teramo, Teramo, Italy.ORCID https://orcid.org/0000-0002-9759-2449
Mauro MaccarroneDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Funding

InMed Pharmaceuticals PCI0029
6 · The paper itself

Abstract

Cannabinol (CBN) is a secondary metabolite of cannabis whose beneficial activity on inflammatory diseases of human skin has attracted increasing attention. Here, we sought to investigate the possible modulation by CBN of the major elements of the endocannabinoid system (ECS), in both normal and lipopolysaccharide-inflamed human keratinocytes (HaCaT cells). CBN was found to increase the expression of cannabinoid receptor 1 (CB

Indexed as

Anti-Inflammatory AgentsArachidonic AcidsCannabinolEndocannabinoidsKeratinocytesPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1TRPV Cation ChannelsAmidohydrolasesFatty Acid Amide HydrolasesGlyceridesHaCaT CellsHumansInflammationInterleukin-12Interleukin-8AmidohydrolasesanandamideAnti-Inflammatory AgentsArachidonic AcidsCannabinolEndocannabinoidsFatty Acid Amide HydrolasesGlyceridesglyceryl 2-arachidonateInterleukin-12Interleukin-8InterleukinsLipopolysaccharidesMonoacylglycerol LipasesNAPEPLD protein, humanPhospholipase DPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1TRPV1 protein, humanTRPV Cation Channelscannabinolcytokinesendocannabinoid systemkeratinocytesskin inflammation

Identifiers

PMID39275884
PMCPMC11681214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.