Evidence map›Paper›PMID 39275315›Full record

Trial reportNutrients2024

The Clinical Effect of a Propolis and Mangosteen Extract Complex in Subjects with Gingivitis: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.

Jae-Suk Jung, Geum-Hee Choi, Heelim Lee, Youngkyung Ko, Suk Ji

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jae-Suk JungDepartment of Periodontology, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Geum-Hee ChoiDepartment of Periodontology, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Heelim LeeDepartment of Periodontology, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Youngkyung KoDepartment of Dentistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0002-6564-9156
Suk JiDepartment of Periodontology, Institute of Oral Health Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea.ORCID 0000-0001-9720-6731

Funding

Medibio Lab Co., Ltd none
6 · The paper itself

Abstract

This study investigated the efficacy and safety of a propolis-mangosteen extract complex (PMEC) on gingival health in patients with gingivitis and incipient periodontitis. A multicentered, randomized, double-blind, placebo-controlled trial involving 104 subjects receiving either PMEC or placebo for eight weeks was conducted. The primary focus was on the changes in inflammatory biomarkers from gingival crevicular fluid (GCF), with clinical parameters as secondary outcomes. The results revealed that the PMEC group showed a significantly reduced expression of all measured GCF biomarkers compared to the placebo group (

Indexed as

GingivitisPlant ExtractsPropolisAdultBiomarkersDinoprostoneDouble-Blind MethodFemaleGarcinia mangostanaGingivaGingival Crevicular FluidHumansInflammation MediatorsInterleukin-1betaMaleMatrix Metalloproteinase 8BiomarkersDinoprostoneInflammation MediatorsInterleukin-1betaMatrix Metalloproteinase 8Matrix Metalloproteinase 9MMP8 protein, humanMMP9 protein, humanPlant ExtractsPropolisanti-inflammatory effectgingivitismangosteenpropolis

Identifiers

PMID39275315
PMCPMC11396876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.