Evidence map›Paper›PMID 39275225›Full record

ArticleNutrients2024

Longitudinal Dietary Intake Data in Patients with Phenylketonuria from Europe: The Impact of Age and Phenylketonuria Severity.

Alex Pinto, Kirsten Ahring, Manuela Ferreira Almeida, Catherine Ashmore, Amaya Bélanger-Quintana, Alberto Burlina, Turgay Coşkun, Anne Daly, Esther van Dam, Ali Dursun and 19 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Alex PintoBirmingham Children's Hospital, Birmingham B4 6NH, UK.
Kirsten AhringDepartment of PKU, Copenhagen University Hospital, 2100 København, Denmark.
Manuela Ferreira AlmeidaCentro de Genética Médica, Unidade Local de Saúde de Santo António, E.P.E. (ULSSA), 4099-028 Porto, Portugal.ORCID 0000-0002-1683-1314
Catherine AshmoreBirmingham Children's Hospital, Birmingham B4 6NH, UK.
Amaya Bélanger-QuintanaUnidad de Enfermedades Metabólicas Congénitas, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0003-0102-8956
Alberto BurlinaDivision of Inherited Metabolic Diseases, Reference Centre Expanded Newborn Screening, Department of Women's and Children's Health, University Hospital, 35128 Padova, Italy.ORCID 0000-0001-7724-137X
Turgay CoşkunDepartment of Pediatric Metabolism and Nutrition, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Anne DalyBirmingham Children's Hospital, Birmingham B4 6NH, UK.ORCID 0000-0003-2579-8699
Esther van DamDivision of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Ali DursunDepartment of Pediatric Metabolism and Nutrition, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Sharon EvansBirmingham Children's Hospital, Birmingham B4 6NH, UK.ORCID 0000-0002-7654-3621
François FeilletDepartment of Paediatrics, Reference Center for Inborn Errors of Metabolism, Hôpital d'Enfants Brabois, CHU Nancy, 54500 Vandoeuvre les Nancy, France.ORCID 0000-0002-8717-469X
Maria GiżewskaDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology of the Developmental Age, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0001-8433-0864
Hulya Gökmen-ÖzelDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, 06100 Ankara, Turkey.
Mary HicksonSchool of Health Professions, Faculty of Health, University of Plymouth, Plymouth PL4 6AB, UK.ORCID 0000-0001-7996-0095
Yteke HoekstraDivision of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Fatma IlgazDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, 06100 Ankara, Turkey.
Richard JacksonCancer Research UK Liverpool Cancer Trials Unit, University of Liverpool, Liverpool L69 3GL, UK.
Alicja LeśniakDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology of the Developmental Age, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0002-0760-5120
Christian LoroDivision of Inherited Metabolic Diseases, Reference Centre Expanded Newborn Screening, Department of Women's and Children's Health, University Hospital, 35128 Padova, Italy.
Katarzyna MalickaDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology of the Developmental Age, Pomeranian Medical University, 70-204 Szczecin, Poland.
Michał PatalanDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology of the Developmental Age, Pomeranian Medical University, 70-204 Szczecin, Poland.ORCID 0000-0002-5981-6456
Júlio César RochaNutrition and Metabolism, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.ORCID 0000-0002-4977-8345
Serap SivriDepartment of Pediatric Metabolism and Nutrition, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.ORCID 0000-0001-8260-9984
Iris RodenburgDivision of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Francjan van SpronsenDivision of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-3773-1929
Kamilla StrączekDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases, and Cardiology of the Developmental Age, Pomeranian Medical University, 70-204 Szczecin, Poland.
Ayşegül TokatliDepartment of Pediatric Metabolism and Nutrition, Faculty of Medicine, Hacettepe University, 06230 Ankara, Turkey.
Anita MacDonaldBirmingham Children's Hospital, Birmingham B4 6NH, UK.

Funding

Biomarin Biomarin independent research grant
6 · The paper itself

Abstract

In phenylketonuria (PKU), natural protein intake is thought to increase with age, particularly during childhood and adolescence. Longitudinal dietary intake data are scarce and lifelong phenylalanine tolerance remains unknown. Nine centres managing PKU in Europe and Turkey participated in a retrospective study. Data were collected from dietetic records between 2012 and 2018 on phenylalanine (Phe), natural protein, and protein substitute intake. A total of 1323 patients (age range: 1-57 y; 51% male) participated. Dietary intake data were available on 1163 (88%) patients. Patient numbers ranged from 59 to 320 in each centre. A total of 625 (47%) had classical PKU (cPKU),

Indexed as

PhenylalaninePhenylketonuriasAdolescentAdultAge FactorsChildChild, PreschoolDietary ProteinsEuropeFemaleHumansInfantLongitudinal StudiesMaleMiddle AgedRetrospective StudiesDietary ProteinsPhenylalaninenatural protein intakephenylalanine intakephenylketonuriaprotein equivalent from protein substitute intaketotal protein intake

Identifiers

PMID39275225
PMCPMC11396810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.