Evidence map›Paper›PMID 39275206›Full record

Trial reportNutrients2024

Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function.

Simon D Bowles, Richard Jacques, Thomas R Hill, Richard Eastell, Jennifer S Walsh

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Simon D BowlesFood and Nutrition Subject Group, Stoddart Building, Sheffield Hallam University, City Campus, Arundel Gate, Sheffield S1 1WB, UK.ORCID 0000-0001-5935-8187
Richard JacquesMedical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK.ORCID 0000-0001-6710-5403
Thomas R HillMRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Richard EastellMRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-0323-3366
Jennifer S WalshMRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-7122-2650

Funding

Royal Osteoporosis Society 235/366
6 · The paper itself

Abstract

High dose bolus cholecalciferol supplementation has been associated with falls and fracture, and this does not appear to be due to hypercalcaemia. The primary aim of this study was to determine the change in free vitamin D and metabolites after high dose bolus supplementation. This was a single centre, double-blinded, randomised, controlled trial of three different oral bolus doses of vitamin D

Indexed as

BiomarkersBone RemodelingCholecalciferolDietary SupplementsVitamin DVitamin D DeficiencyAgedCalciumDose-Response Relationship, DrugDouble-Blind MethodFemaleFibroblast Growth Factor-23HumansMiddle AgedParathyroid HormonePostmenopauseBiomarkersCalciumCholecalciferolFibroblast Growth Factor-23Parathyroid HormoneVitamin Dbolus dose vitamin Dbone turnoverfalls and fracturefree vitamin Dphysical functionvitamin D supplementationvitamin D toxicity

Identifiers

PMID39275206
PMCPMC11397043

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.