Evidence map›Paper›PMID 39275173›Full record

Trial reportNutrients2024

Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males.

Mohammad Ahmadi Moqaddam, Morteza Nemati, Marjan Mansouri Dara, Maha Hoteit, Zahra Sadek, Akbar Ramezani, Mahboubeh Khak Rand, Asieh Abbassi-Daloii, Zhaleh Pashaei, Abdullah Almaqhawi and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genes · 2025
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mohammad Ahmadi MoqaddamDepartment of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran.
Morteza NematiDepartment of Biomechanics and Sports Injuries, Faculty of Physical Education and Sports Sciences, Kharazmi University, Tehran 1571914911, Iran.
Marjan Mansouri DaraDepartment of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran.
Maha HoteitFood Science Unit, National Council for Scientific Research of Lebanon (CNRS-L), Beirut 11-8281, Lebanon.ORCID 0000-0001-7392-4835
Zahra SadekSection 1, Faculty of Public Health, Lebanese University, Beirut 6573, Lebanon.ORCID 0000-0003-4985-8465
Akbar RamezaniAyatollah Amoli Branch, Department of Exercise Physiology, Islamic Azad University, Amol 6134937333, Iran.
Mahboubeh Khak RandAyatollah Amoli Branch, Department of Exercise Physiology, Islamic Azad University, Amol 6134937333, Iran.
Asieh Abbassi-DaloiiAyatollah Amoli Branch, Department of Exercise Physiology, Islamic Azad University, Amol 6134937333, Iran.
Zhaleh PashaeiDepartment of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz 5166616471, Iran.
Abdullah AlmaqhawiDepartment of Family Medicine and Community, College of Medicine, King Faisal University, Al Ahsa 31982, Saudi Arabia.ORCID 0000-0001-6035-1230
Omid RaziDepartment of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah 6714414971, Iran.ORCID 0000-0002-6364-7309
Kurt A EscobarDepartment of Kinesiology, California State University, Long Beach, CA 90840, USA.ORCID 0000-0002-5094-6895
Rashmi SupriyaCentre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China.ORCID 0000-0003-2995-1910
Ayoub SaeidiDepartment of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj 1517566177, Iran.ORCID 0000-0003-2458-6256
Hassane ZouhalM2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, Université Rennes, 35044 Rennes, France.ORCID 0000-0001-6743-6464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity is associated with an exacerbated metabolic condition that is mediated through impairing balance in the secretion of some adipo-myokines. Therefore, the objective of the present study was to explore the impact of astaxanthin supplementation in conjunction with a 12-week CrossFit training regimen on some selected adipo-myokines, insulin insensitivity, and serum lipid levels in obese males. MATERIAL AND

methodsThis study is a randomized control trial design; 60 obese males were randomly divided into four groups of 15, including the control group (CG), supplement group (SG), training group (TG), and combined training and supplement group (TSG). The participants were subjected to 12 weeks of astaxanthin (AST) supplementation [20 mg/d capsule, once/d] or CrossFit training or a combination of both interventions. The training regimen comprised 36 sessions of CrossFit, each lasting 60 min, conducted three times per week. The metabolic indices, body composition, anthropometrical, cardio-respiratory, and also some plasma adipo-myokine factors, including decorin (DCN), activin A, myostatin (MST), transforming growth factor (TGF)-β1, and follistatin (FST), were examined 12 and 72 h before the initiation of the main interventional protocols, and then 72 h after the final session of the training protocol.

resultsThere was no significant difference in the baseline data between the groups (

conclusionsThe 12-week CrossFit training concurrent with AST supplementation reduced anthropometric and metabolic factors and also serum lipid levels while producing positive changes in body composition and cardiovascular factors. Increased FST and DCN and reduced activin A, MST, and TGF-β1 were other affirmative responses to both interventions.

Indexed as

Dietary SupplementsMyostatinObesityXanthophyllsAdipokinesAdultBody CompositionDecorinExerciseFollistatinHumansInsulin ResistanceLipidsMaleMyokinesTransforming Growth Factor beta1AdipokinesastaxanthineDecorinFollistatinLipidsMSTN protein, humanMyokinesMyostatinTGFB1 protein, humanTransforming Growth Factor beta1Xanthophyllsastaxanthin supplementationexercisemyokinesobesity

Identifiers

PMID39275173
PMCPMC11397083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.