Evidence map›Paper›PMID 39275127›Full record

ReviewMolecules (Basel, Switzerland)2024

Promising Therapeutic Strategies for Hematologic Malignancies: Innovations and Potential.

Jan Jakub Lica, Bhaskar Pradhan, Kawthar Safi, Joanna Jakóbkiewicz-Banecka, Andrzej Hellmann

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Molecular Insights and Novel Therapies for Lymphoproliferative Disorders.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Chemoimmunotherapy synergism: mechanisms and clinical applications.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Hematological Malignancies: Molecular Mechanisms and Therapy.International journal of molecular sciences · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jan Jakub LicaFaculty of Health Science, Powiśle University, 80-214 Gdańsk, Poland.ORCID 0000-0001-6374-3635
Bhaskar PradhanDepartment of Biochemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-2751-1428
Kawthar SafiDepartment of Biochemistry and Clinical Chemistry, Faculty of Biology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-1325-7094
Joanna Jakóbkiewicz-BaneckaDepartment Medical Biology and Genetics, Faculty of Biology, University of Gdańsk, 80-308 Gdańsk, Poland.ORCID 0000-0002-8846-5448
Andrzej HellmannDepartment of Hematology and Transplantology, Faculty of Medicine, Medical University of Gdańsk, 80-214 Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review we explore innovative approaches in the treatment of hematologic cancers by combining various therapeutic modalities. We discuss the synergistic potential of combining inhibitors targeting different cellular pathways with immunotherapies, molecular therapies, and hormonal therapies. Examples include combining PI3K inhibitors with proteasome inhibitors, NF-κB inhibitors with immunotherapy checkpoint inhibitors, and neddylation inhibitors with therapies targeting the tumor microenvironment. Additionally, we discuss the potential use of small molecules and peptide inhibitors in hematologic cancer treatment. These multidimensional therapeutic combinations present promising strategies for enhancing treatment efficacy and overcoming resistance mechanisms. However, further clinical research is required to validate their effectiveness and safety profiles in hematologic cancer patients.

Indexed as

Hematologic NeoplasmsAnimalsAntineoplastic AgentsHumansImmunotherapyMolecular Targeted TherapyProteasome InhibitorsTumor MicroenvironmentAntineoplastic AgentsProteasome Inhibitorshematologic cancersimmunotherapy checkpoint inhibitorsinnovative approachesneddylation inhibitorsNF-κB inhibitorsPI3K inhibitorsproteasome inhibitorssmall moleculessynergistic potentialtherapeutic modalities

Identifiers

PMID39275127
PMCPMC11397263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.