Evidence map›Paper›PMID 39275124›Full record

ArticleMolecules (Basel, Switzerland)2024

Polyamine Derived Photosensitizer: A Novel Approach for Photodynamic Therapy of Cancer.

Hao Deng, Ke Xie, Liling Hu, Xiaowen Liu, Qingyun Li, Donghui Xie, Fengyi Xiang, Wei Liu, Weihong Zheng, Shuzhang Xiao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hao DengHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Ke XieHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Liling HuThe First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China.
Xiaowen LiuHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Qingyun LiHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Donghui XieHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Fengyi XiangHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Wei LiuThe First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China.
Weihong ZhengHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
Shuzhang XiaoCollege of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.
Jun ZhengThe First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China.
Xiao TanHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.

Funding

Applied Natural Science Fund of China Three Gorges University SDHZ2021245, SDHZ20230118Hubei Provincial Natural Science Foundation for Innovative Development Joint Fund Project 2024AFD172National Natural Science Foundation of China 81602743Open Fund of Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University 2023KZL02, 2022KZL2-06Yichang Municipal Medical and Health Research Project Fund A21-2-003
6 · The paper itself

Abstract

Polyamines play a pivotal role in cancer cell proliferation. The excessive polyamine requirement of these malignancies is satisfied through heightened biosynthesis and augmented extracellular uptake via the polyamine transport system (PTS) present on the cell membrane. Meanwhile, photodynamic therapy (PDT) emerges as an effective anti-cancer treatment devoid of drug resistance. Recognizing these intricacies, our study devised a novel polyamine-derived photosensitizer (PS) for targeted photodynamic treatment, focusing predominantly on pancreatic cancer cells. We synthesized and evaluated novel spermine-derived fluorescent probes (N2) and PS (N3), exhibiting selectivity towards pancreatic cancer cells via PTS. N3 showed minimal dark toxicity but significant phototoxicity upon irradiation, effectively causing cell death in vitro. A significant reduction in tumor volume was observed post-treatment with no pronounced dark toxicity using the pancreatic cancer CDX mouse model, affirming the therapeutic potential of N3. Overall, our findings introduce a promising new strategy for cancer treatment, highlighting the potential of polyamine-derived PSs in PDT.

Indexed as

PhotochemotherapyPhotosensitizing AgentsPolyaminesAnimalsCell Line, TumorCell ProliferationHumansMicePancreatic NeoplasmsXenograft Model Antitumor AssaysPhotosensitizing AgentsPolyaminescancerphotodynamic therapyphotosensitizerpolyamine transport system

Identifiers

PMID39275124
PMCPMC11397399

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.