Synthesis and Anticancer Activity of 3,4-Diaryl-1,2-dihydro- and 1,2,3,4-Tetrahydroquinolines.

Santosh Rajput, Valerio Falasca, Mohan Bhadbhade, David StC Black, Naresh Kumar

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Santosh RajputSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

Valerio FalascaSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-3592-9034

Mohan BhadbhadeSolid State and Elemental Analysis Unit, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW 2052, Australia.

David StC BlackSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-9300-4737

Naresh KumarSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0951-9621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrahydroquinolines are key structures in a variety of natural products with diverse pharmacological utilities and other applications. A series of 3,4-diaryl-5,7-dimethoxy-1,2,3,4-tetrahydroquinolines were synthesized in good yield by reacting 3-aryl-5,7-dimethoxy-2,3-dihydroquinolin-4-ones with different Grignard reagents followed by the dehydration of the intermediate phenolic compounds. Subsequent reduction and deprotection were carried out to achieve the desired tetrahydroquinolone moiety. The lead compound

Indexed as

Antineoplastic AgentsQuinolinesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity Relationship1,2,3,4-tetrahydroquinolineAntineoplastic AgentsQuinolinesdehydrationdihydroquinolin-4-onesGrignard reactionshydrogenationquinolonestetrahydroquinolines

Identifiers

PMID39275120

DOI10.3390/molecules29174273

PMCPMC11396787

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.