Evidence map›Paper›PMID 39275061›Full record

ReviewMolecules (Basel, Switzerland)2024

TSPO Radioligands for Neuroinflammation: An Overview.

Silvia Salerno, Monica Viviano, Emma Baglini, Valeria Poggetti, Doralice Giorgini, Jacopo Castagnoli, Elisabetta Barresi, Sabrina Castellano, Federico Da Settimo, Sabrina Taliani

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Multifunctional auranofin analogues: dual-targeting TSPO/TrxR gold(I) complexes with activity in resistant ovarian cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  3. Influence of Translocator Protein (Life (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Contrast-enhanced TScientific reports · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Silvia SalernoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-6072-4698
Monica VivianoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.ORCID 0000-0003-1118-790X
Emma BagliniDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Valeria PoggettiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Doralice GiorginiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Jacopo CastagnoliDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Elisabetta BarresiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-9814-7195
Sabrina CastellanoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Federico Da SettimoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-7897-7917
Sabrina TalianiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0001-8675-939X

Funding

Italian Ministry of Education, Universities and Research (MIUR) by the funding of "projects of national interest 2022CF5T454
6 · The paper itself

Abstract

The translocator protein (TSPO) is predominately localized on the outer mitochondrial membrane in steroidogenic cells. In the brain, TSPO expression, low under normal conditions, results upregulated in response to glial cell activation, that occurs in neuroinflammation. As a consequence, TSPO has been extensively studied as a biomarker of such conditions by means of TSPO-targeted radiotracers. Although [

Indexed as

Neuroinflammatory DiseasesReceptors, GABAAnimalsBrainHumansIsoquinolinesLigandsPositron-Emission TomographyRadiopharmaceuticalsIsoquinolinesLigandsRadiopharmaceuticalsReceptors, GABATSPO protein, humandiagnostic markerneuroinflammationradioligandtranslocator protein

Identifiers

PMID39275061
PMCPMC11397380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.