Evidence map›Paper›PMID 39274943›Full record

ArticleMolecules (Basel, Switzerland)2024

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin.

Wjdan Jogadi, Man B Kshetri, Suha Alqarni, Arpit Sharma, May Cheline, Md Al Amin, Cynthia Sheets, Angele Nsoure-Engohang, Yao-Rong Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wjdan JogadiDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.ORCID 0009-0009-0503-2961
Man B KshetriDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.ORCID 0000-0002-4673-4662
Suha AlqarniDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.ORCID 0000-0001-7923-9257
Arpit SharmaDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.
May ChelineDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.ORCID 0000-0001-6768-9197
Md Al AminDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.
Cynthia SheetsDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.
Angele Nsoure-EngohangDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.
Yao-Rong ZhengDepartment of Chemistry and Biochemistry, Kent State University, 236 Integrated Sciences Building, Kent, OH 44242, USA.

Funding

Development of Novel Metal-Based Supramolecular Therapeutics for Ovarian CancerR15CA249712 · NCI · KENT STATE UNIVERSITY · PI ZHENG, YAORONG · 2021 to 2021
$455k
Kent State University Farris Family Innovation FellowshipKent State University LaunchPad AwardKent State University Small Research GrantNational Science Foundation 2050873NIH HHS 1R15CA249712-01A1
6 · The paper itself

Abstract

In this study, we report a novel platinum-doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment. This new molecular structure (

Indexed as

CisplatinDoxorubicinAntineoplastic AgentsCell Line, TumorCell SurvivalDNA DamageHistonesHumansPlatinumProdrugsAntineoplastic AgentsCisplatinDoxorubicinH2AX protein, humanHistonesPlatinumProdrugscisplatincombination therapydoxorubicinplatinum(IV) prodrugs

Identifiers

PMID39274943
PMCPMC11397443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.