ArticleMolecules (Basel, Switzerland)2024
Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells.
Anna Aleksandrova, Arif Mekhtiev, Olga Timoshenko, Elena Kugaevskaya, Tatiana Gureeva, Alisa Gisina, Maria Zavialova, Kirill Scherbakov, Anton Rudovich, Vladimir Zhabinskii and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Anna AleksandrovaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Arif MekhtievInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Olga TimoshenkoInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Elena KugaevskayaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Tatiana GureevaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Alisa GisinaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.ORCID 0000-0001-7691-9265 Maria ZavialovaInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.ORCID 0000-0003-0761-2299 Kirill ScherbakovInstitute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Str., 119121 Moscow, Russia.
Anton RudovichInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str., 5/2, 220084 Minsk, Belarus.ORCID 0000-0003-3521-727X Vladimir ZhabinskiiInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str., 5/2, 220084 Minsk, Belarus.ORCID 0000-0001-8591-2794 Vladimir KhripachInstitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str., 5/2, 220084 Minsk, Belarus.ORCID 0000-0002-3850-9860 Funding
Ministry of Science and Higher Education of the Russian Federation and Belarusian Foundation for Fundamental Research No 075-15-2022-305 and grant number X22Mldg-001
6 · The paper itselfAbstract
Activation of the Hedgehog (Hh) signaling pathway is often associated with the progression of various types of cancer. The purpose of study was to search for inhibitors of the Hh signaling pathway among eight compounds belonging to the group of isoxazolyl steroids. The evaluation of the effectiveness of the compounds was based on the analysis of their cytotoxicity, effect on the cell cycle, on the expression of key Hh-signaling-pathway genes (Ptch1, Smo, and Gli1) and putative target genes MMP-2 and MMP-9. Four compounds with the most pronounced cytotoxic effect were identified: compounds
Indexed as
Gene Expression Regulation, NeoplasticHedgehog ProteinsSignal TransductionSteroidsA549 CellsAntineoplastic AgentsCell CycleCell Line, TumorHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Patched-1 ReceptorSmoothened ReceptorZinc Finger Protein GLI1Antineoplastic AgentsGLI1 protein, humanHedgehog ProteinsMatrix Metalloproteinase 2Matrix Metalloproteinase 9Patched-1 ReceptorSHH protein, humanSmoothened ReceptorSteroidsZinc Finger Protein GLI1cancer cell proliferationHh receptorsisoxazolesMMPsteroids
Identifiers
PMID39274874
PMCPMC11396458
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