Evidence map›Paper›PMID 39274859›Full record

ArticleMolecules (Basel, Switzerland)2024

Synthesis and Biological Evaluation of Novel Piperidine-3-Carboxamide Derivatives as Anti-Osteoporosis Agents Targeting Cathepsin K.

Yali Wang, Ting Guan, Hegen Xiong, Wenxin Hu, Xianjian Zhu, Yuanyuan Ma, Zhiqing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Asymmetric Rh-Catalyzed Synthesis of Dihydronicotinamides.The Journal of organic chemistry · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yali WangSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.
Ting GuanSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.
Hegen XiongSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.
Wenxin HuSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.
Xianjian ZhuSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.
Yuanyuan MaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Zhiqing ZhangSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332005, China.

Funding

Jiangxi Provincial Natural Science Foundation 20232BAB20617National Natural Science Foundation of China 21867013
6 · The paper itself

Abstract

A series of novel piperidamide-3-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against cathepsin K. Among these derivatives, compound

Indexed as

Cathepsin KMolecular Docking SimulationOsteoporosisPiperidinesAnimalsBone DensityBone ResorptionFemaleHumansMiceMolecular StructureRANK LigandRAW 264.7 CellsStructure-Activity RelationshipCathepsin KPiperidinesRANK Ligandanti-osteoporosiscathepsin K inhibitorspiperidamide-3-carboxamide derivativessynthesis

Identifiers

PMID39274859
PMCPMC11396514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.