Evidence map›Paper›PMID 39274838›Full record

ArticleMolecules (Basel, Switzerland)2024

Lupeol-3-carbamate Derivatives: Synthesis and Biological Evaluation as Potential Antitumor Agents.

Shuang Tian, Yinxu Zhao, Siqi Deng, Liman Hou, Juan Song, Ming Wang, Ming Bu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuang TianCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Yinxu ZhaoCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Siqi DengCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Liman HouCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Juan SongCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Ming WangCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.
Ming BuCollege of Pharmacy, Qiqihar Medical University, Qiqihar 161006, China.ORCID 0000-0001-9752-0886

Funding

Postdoc-toral Research Project of Heilongjiang Province LBH-QY24003Qiqihar Science and Technology Bureau of China LSFGG-2023026
6 · The paper itself

Abstract

In the following study, a series of new lupeol-3-carbamate derivatives were synthesized, and the structures of all the newly derived compounds were characterized. The new compounds were screened to determine their anti-proliferative activity against human lung cancer cell line A549, human liver cancer cell line HepG2, and human breast cancer cell line MCF-7. Most of the compounds were found to show better anti-proliferative activity in vitro than lupeol. Among them, obvious anti-proliferation activity (IC

Indexed as

Antineoplastic AgentsApoptosisCarbamatesCell ProliferationPentacyclic TriterpenesA549 CellsCell Line, TumorDrug Screening Assays, AntitumorHep G2 CellsHumansLupanesMCF-7 CellsMolecular StructurePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAntineoplastic AgentsCarbamatesLupaneslupeolPentacyclic TriterpenesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesantitumorcarbamatehybridlupeolstructural modification

Identifiers

PMID39274838
PMCPMC11396318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.