Biocompatibility Evaluation of an Artificial Metallic Bone with Lattice Structure for Reconstruction of Bone Defect.

Erika Yasuge, Tadashi Kawai, Shinsuke Kawamata, Isao Hoshi, Tadaharu Minamino, Shingo Kurosu, Hiroyuki Yamada

Abstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Erika YasugeDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan.

Tadashi KawaiDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan.ORCID 0000-0002-2712-1895

Shinsuke KawamataDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan.ORCID 0000-0002-9858-7262

Isao HoshiDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan.

Tadaharu MinaminoDepartment of Elementary Material Process Technology, Iwate Industrial Research Institute, 2-4-25, Kitaiioka, Morioka 020-0857, Japan.

Shingo KurosuDepartment of Elementary Material Process Technology, Iwate Industrial Research Institute, 2-4-25, Kitaiioka, Morioka 020-0857, Japan.

Hiroyuki YamadaDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, Morioka 020-8505, Japan.

Funding

Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan 22K10132, 23K09360

6 · The paper itself

Abstract

Mandibular reconstruction for large bone defects is performed with consideration of patients' specific morphology and sufficient strength. Metal additive manufacturing techniques have been used to develop biomaterials for mandibular reconstruction. Titanium artificial mandibles with a lattice structure have been proposed, and the optimal conditions for their strength to withstand mechanical stress around the mandible have been reported. This study investigated the biocompatibility of a titanium artificial bone with a lattice structure fabricated under optimal conditions. The samples were fabricated using metal additive manufacturing. Body diagonals with nodes (BDN) were selected as suitable lattice structures. Dode medium (DM) was selected for comparison. The samples were implanted into rabbit tibial defects and resected with the surrounding bone at two and four weeks. Specimens were evaluated radiographically, histologically, and histomorphometrically. Radiopacity in each lattice structure was observed at two and four weeks. Histological evaluation showed trabecular bone-like tissue inside the BDN compared to the DM at four weeks. No significant differences were noted in the bone volume inside the structures. This study demonstrated the in vivo compatibility of artificial metallic bones with a BDN structure under mechanical stress conditions.

Indexed as

biocompatibilitylattice structuremandibular reconstructionmechanical stressmetallic artificial bone

Identifiers

PMID39274676

DOI10.3390/ma17174286

PMCPMC11395923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.