ReviewJournal of clinical medicine2024
The Spectrum of Coronary Artery Disease in Elite Endurance Athletes-A Long-Standing Debate: State-of-the-Art Review.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coronary Artery Disease in Masters Athletes: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Exercise-Induced Coronary Remodeling and the Atherosclerotic Paradox in Endurance Athletes: Toward a Unified Mechanobiological Framework.Journal of functional morphology and kinesiology · 2026Review
- Resilience against exercise-related coronary atherosclerosis: A case study in a master athlete participating in 500 marathons.Sports medicine and health science · 2026Article
- Marathon-associated sudden cardiac death: a mini review of risk perception, pathophysiological mechanisms, and prevention strategies.Frontiers in cardiovascular medicine · 2026Review
- Role of exercise in cardiovascular health: a narrative review from prevention to therapeutic utilizations.Frontiers in cardiovascular medicine · 2026Review
- The influence of high exercise levels on the coronary atherosclerosis profile by computed tomography angiography and outcomes.American journal of preventive cardiology · 2025Article
- Athlete's Heart Revisited: Historical, Clinical, and Molecular Perspectives.Circulation research · 2025Review
- The Importance of Vitamin D and Magnesium in Athletes.Nutrients · 2025Review
- Optimized Lightweight Architecture for Coronary Artery Disease Classification in Medical Imaging.Diagnostics (Basel, Switzerland) · 2025Article
- Exploring the Needs and Preferences of Athletes in Cardiac (Tele)Rehabilitation to Enhance Rehabilitation Outcome: A Qualitative Study.Patient preference and adherence · 2025Article
- Myocardial bridging resulting in an atypical acute coronary syndrome in a young athlete: a case report.European heart journal. Case reports · 2025Article
- Inflammation and depression: an evolutionary framework for the role of physical activity and exercise.Frontiers in psychology · 2025Review
- The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation.Biomolecules · 2024Review
- Lipid Accumulation Product and Cardiometabolic Index as Effective Tools for the Identification of Athletes at Risk for Metabolic Syndrome.Life (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity is recommended for the prevention of primary and secondary cardiovascular (CV) disease as it is linked to a number of health benefits, especially CV. However, recent research suggests that high-volume, long-term endurance exercise may hasten rather than slow the coronary atherosclerosis progression. This contentious theory has generated a great discussion and is still a major source of doubt when it comes to the clinical treatment of coronary artery disease (CAD) in athletes. CAD is the primary cause of sudden cardiac death in athletes over 35 years. Thus, recent studies evaluated the prevalence of CAD in athletes and its clinical and prognostic implications. Indeed, many studies have shown a relationship between endurance sports and higher volumes of coronary calcified plaque as determined by computed tomography. However, the precise pathogenetic substrate for the existence of an increased coronary calcification burden among endurance athletes remains unclear. Moreover, the idea that coronary plaques in elite athletes present a benign morphology has been cast into doubt by some recent studies showing potential association with adverse cardiovascular events. This review aims to analyze the association between physical activity and CAD, explaining possible underlying mechanisms of atherosclerotic progression and non-ischemic coronary lesions, focusing primarily on clinical and prognostic implications, multimodal evaluation, and management of CAD in endurance athletes.
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Registered trials
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