Evidence map›Paper›PMID 39274195›Full record

ReviewJournal of clinical medicine2024

Ranolazine Unveiled: Rediscovering an Old Solution in a New Light.

Giulia Azzurra De Santis, Tommaso De Ferrari, Francesca Parisi, Marco Franzino, Agustin Ezequiel Molinero, Alessandro Di Carlo, Lorenzo Pistelli, Giampaolo Vetta, Antonio Parlavecchio, Marco Torre and 9 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giulia Azzurra De SantisCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Tommaso De FerrariCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Francesca ParisiClinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), 90127 Palermo, Italy.ORCID 0009-0003-1228-5760
Marco FranzinoS.C. Cardiologia, Ospedale Sant'Andrea, 13100 Vercelli, Italy.ORCID 0009-0008-1702-6908
Agustin Ezequiel MolineroCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Alessandro Di CarloCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Lorenzo PistelliSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0002-8146-109X
Giampaolo VettaHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, 1050 Brussels, Belgium.ORCID 0000-0002-1120-0492
Antonio ParlavecchioCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.ORCID 0000-0002-7122-6053
Marco TorreSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0009-0007-9119-3512
Matteo ParolloSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Giacomo MansiSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Pietro Paolo TamborrinoSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Antonio CanuSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Gino GrifoniSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Luca SegretiSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Andrea Di CoriSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0002-3083-7376
Stefano Marco VianiSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.
Giulio ZucchelliSecond Division of Cardiology, Cardio-Thoracic and Vascular Department, Pisa University Hospital, 56124 Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ranolazine is an anti-anginal medication that has demonstrated antiarrhythmic properties by inhibiting both late sodium and potassium currents. Studies have shown promising results for ranolazine in treating both atrial fibrillation and ventricular arrhythmias, particularly when used in combination with other medications. This review explores ranolazine's mechanisms of action and its potential role in cardiac arrhythmias treatment in light of previous clinical studies.

Indexed as

arrhythmiasatrial fibrillationranolazinesodium current inhibitionventricular arrhythmias

Identifiers

PMID39274195
PMCPMC11396555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.