Evidence map›Paper›PMID 39273691›Full record

ArticleInternational journal of molecular sciences2024

Synthesis of Ethyl Pyrimidine-Quinolincarboxylates Selected from Virtual Screening as Enhanced Lactate Dehydrogenase (LDH) Inhibitors.

Iván Díaz, Sofía Salido, Manuel Nogueras, Justo Cobo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Excavating Precursors from Herb PairsPharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Synthesis andInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iván DíazFacultad de Ciencias Experimentales, Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, E-23071 Jaén, Spain.ORCID 0000-0002-7077-9772
Sofía SalidoFacultad de Ciencias Experimentales, Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, E-23071 Jaén, Spain.ORCID 0000-0003-2319-7873
Manuel NoguerasFacultad de Ciencias Experimentales, Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, E-23071 Jaén, Spain.ORCID 0000-0001-5976-0387
Justo CoboFacultad de Ciencias Experimentales, Departamento de Química Inorgánica y Orgánica, Universidad de Jaén, E-23071 Jaén, Spain.ORCID 0000-0001-9184-2390

Funding

Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía, Spain) FQM-182Ministerio de Ciencia, Innovación, y Universidades, Spain PID2022-141783OB-C22Vicerrectorado de Investigación, Universidad de Jaén PAIUJA "acción 1 plan 2021-2022"
6 · The paper itself

Abstract

The inhibition of the hLDHA (human lactate dehydrogenase A) enzyme has been demonstrated to be of great importance in the treatment of cancer and other diseases, such as primary hyperoxalurias. In that regard, we have designed, using virtual docking screening, a novel family of ethyl pyrimidine-quinolinecarboxylate derivatives (

Indexed as

Enzyme InhibitorsL-Lactate DehydrogenaseMolecular Docking SimulationPyrimidinesHumansQuinolinesStructure-Activity RelationshipEnzyme InhibitorsL-Lactate DehydrogenasePyrimidinesQuinolinesethyl pyrimidine-quinolincarboxylateshLDHA/hLDHB inhibitorsisatinsmolecular docking

Identifiers

PMID39273691
PMCPMC11396203

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.