Evidence map›Paper›PMID 39273670›Full record

ArticleInternational journal of molecular sciences2024

Distinct Variations in Gene Expression and Cell Composition across Lichen Planus Subtypes.

Cadri Knoch, Veronika Baghin, Patrick Turko, Nicola Winkelbeiner, Ramon Staeger, Kongchang Wei, Irina Banzola, Mark Mellett, Mitchell P Levesque, Thomas Kuendig and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cadri KnochDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Veronika BaghinDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Patrick TurkoDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-3695-8264
Nicola WinkelbeinerDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Ramon StaegerDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-9283-9596
Kongchang WeiEmpa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Laboratory for Biointerfaces, 9014 St. Gallen, Switzerland.ORCID 0000-0002-6555-2768
Irina BanzolaDepartment of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-5600-7688
Mark MellettDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-6315-167X
Mitchell P LevesqueDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-5902-9420
Thomas KuendigDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-3863-8766
Lars E FrenchDepartment of Dermatology and Allergy, University Hospital, LMU Munich, 80337 Munich, Germany.
Lucie HeinzerlingDepartment of Dermatology and Allergy, University Hospital, LMU Munich, 80337 Munich, Germany.
Barbara Meier-SchiesserDepartment of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-2807-5066

Funding

Swiss Life Foundation 0
6 · The paper itself

Abstract

Lichen planus (LP) is a highly prevalent inflammatory skin disease. While various clinical subtypes have been defined, detailed comparisons of these variants are lacking. This study aimed to elucidate differences in gene expression and cellular composition across LP subtypes. Lesional skin biopsies from 28 LP patients (classical, oral, genital, and lichen planopilaris) and seven non-diseased skin controls (NDC) were analyzed. Gene expression profiling of 730 inflammation-related genes was conducted using NanoString. Immune cell compositions were assessed by multiplex immunohistochemistry. Gene expression profiles revealed unique inflammatory signatures for each LP subtype. Lichen planopilaris exhibited the most divergence, with downregulated gene expression and upregulation of complement pathway genes (

Indexed as

Lichen PlanusAdultAgedFemaleGene Expression ProfilingGene Expression RegulationHumansMacrophagesMaleMiddle AgedSkinTranscriptomeimmune cell infiltratelichen planuslichen planus subtypesmultiplex immunohistochemistryNanoString

Identifiers

PMID39273670
PMCPMC11396712

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.