Pyrroloquinoline Quinone Alleviates Intestinal Inflammation and Cell Apoptosis via the MKK3/6-P38 Pathway in a Piglet Model.

Caiyun Huang, Xuanci Yu, Ziyuan Du, Zhihao Zhu, Chenyu Shi, Ang Li, Fenglai Wang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Dietary pyrroloquinoline quinone supplementation improves productive performance, immunity, and intestinal health in late-phase Jingfen No. 6 laying hens.Poultry science · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caiyun HuangCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Xuanci YuCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Ziyuan DuCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Zhihao ZhuCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Chenyu ShiState Key Laboratory of Animal Nutrition, College of Animal Science & Technology, China Agricultural University, Beijing 100193, China.

Ang LiCollege of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Fenglai WangState Key Laboratory of Animal Nutrition, College of Animal Science & Technology, China Agricultural University, Beijing 100193, China.

Funding

the Earmarked Fund for Modern Agro-industry Technology Research System of China CaRS-43the Education And Scientific Research Project for Young and Middle-aged Teachers of Fujian Provincial Education Department JAT210079the National Natural Science Foundation of China 32202681the Natural Science Foundation of Fujian Province of China 2022J01131269

6 · The paper itself

Abstract

This study investigates the underlying mechanism through which dietary supplementation of pyrroloquinoline quinone disodium (PQQ) alleviates intestinal inflammation and cell apoptosis in piglets challenged with lipopolysaccharide (LPS). Seventy-two barrows were divided into three groups: control (CTRL), LPS challenged (LPS), and LPS challenged with PQQ supplementation (PQQ + LPS). On d 7, 11, and 14, piglets received intraperitoneal injections of LPS or 0.9% of NaCl (80 μg/kg). After a 4 h interval following the final LPS injection on d 14, blood samples were obtained, and all piglets were euthanized for harvesting jejunal samples. The results showed that dietary supplementation of PQQ improved the damage of intestinal morphology, increased the down-regulated tight junction proteins, and reduced the increase of serum diamine oxidase activity, the intestinal fatty acid binding protein, and TNF-α levels in piglets challenged with LPS (

Indexed as

ApoptosisLipopolysaccharidesPQQ CofactorAnimalsDietary SupplementsDisease Models, AnimalInflammationIntestinal MucosaIntestinesMaleMAP Kinase Kinase 3MAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesSwineTight Junction ProteinsLipopolysaccharidesMAP Kinase Kinase 3p38 Mitogen-Activated Protein KinasesPQQ CofactorTight Junction Proteinsapoptosisinflammationintestinepyrroloquinoline quinoneweaned piglets

Identifiers

PMID39273669

DOI10.3390/ijms25179723

PMCPMC11395797

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.